Jung Soonwoong, Son Hyeonwi, Lee Dong Hoon, Roh Gu Seob, Kang Sang Soo, Cho Gyeong Jae, Choi Wan Sung, Kim Hyun Joon
Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
Department of Anatomy and Convergence Medical Science, Bio Anti-aging Medical Research Center, Institute of Health Sciences, Gyeongsang National University Medical School, Jinju, 52727, Republic of Korea.
Biochem Biophys Res Commun. 2016 Mar 25;472(1):276-80. doi: 10.1016/j.bbrc.2016.02.108. Epub 2016 Feb 27.
A healthy acute stress response requires both rapid increase and rapid clearance of blood corticosteroids. We previously showed that regulators of G-protein signaling 4 (RGS4), which decreases in the paraventricular nucleus (PVN) during acute stress, forms a complex with the GABAB receptor. In the present study, we show that this decrease in RGS4 levels in the PVN during an acute stress response facilitates the return of blood corticosteroids to basal levels. Moreover, the effect of RGS4 decrease is attenuated by a GABAB receptor antagonist. These results suggest that RGS4 in the PVN regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.
健康的急性应激反应需要血液中皮质类固醇迅速升高和迅速清除。我们之前发现，G蛋白信号调节因子4（RGS4）在急性应激期间室旁核（PVN）中含量减少，它与GABAB受体形成复合物。在本研究中，我们发现急性应激反应期间PVN中RGS4水平的降低有助于血液中皮质类固醇恢复到基础水平。此外，GABAB受体拮抗剂可减弱RGS4减少的作用。这些结果表明，PVN中的RGS4在急性应激反应期间调节与血液皮质类固醇相关的GABAB受体信号传导。
