Askew C, Lomax J, Lawson W, Kingston R D
Br J Clin Pract. 1989 Dec;43(12):438-42.
A small prospective trial was conducted to evaluate the effectiveness and safety of a single antibiotic regimen, Augmentin, compared with a combination regimen of cefuroxime and metronidazole in the treatment of serious post-operative sepsis. Both regimens used were effective against Bacteroides and other anaerobes, with a similar satisfactory cure rate and no serious side effects. Intravenous Augmentin was easy to use and the change to oral therapy was significantly quicker than in the cefuroxime-metronidazole treatment arm. No significant resistance or serious adverse reaction was noted. The majority of patients had more than one site of infection, making selective antibiotic treatment difficult.
进行了一项小型前瞻性试验，以评估单一抗生素方案阿莫西林克拉维酸钾与头孢呋辛和甲硝唑联合方案在治疗严重术后脓毒症方面的有效性和安全性。所使用的两种方案对拟杆菌属和其他厌氧菌均有效，治愈率相似且令人满意，并且没有严重副作用。静脉注射阿莫西林克拉维酸钾易于使用，改为口服治疗的时间明显快于头孢呋辛-甲硝唑治疗组。未观察到明显耐药性或严重不良反应。大多数患者有不止一个感染部位，使得选择性抗生素治疗困难。
