Mierzynski Radzislaw, Dluski Dominik, Darmochwal-Kolarz Dorota, Poniedziałek-Czajkowska Elzbieta, Leszczynska-Gorzelak Bozena, Kimber-Trojnar Zaneta, Oleszczuk Jan
Department of Obstetrics and Perinatology, Medical University of Lublin, Poland.
Curr Pharm Biotechnol. 2016;17(7):587-96. doi: 10.2174/1389201017666160301104323.
Intra-uterine growth retardation (IUGR) represents one of the major problems in perinatal medicine. IUGR is one of main causes of perinatal mortality and morbidity. A huge number and variety of established and possible causes of IUGR have been described. There are currently no data about effective treatment of this fetal condition. IUGR has been described to be strictly involved in fetal programming. Fetal programming is the general idea, which tells us how during development of the embryo and fetus significant physiological parameters can be shaped by environmental events. A link between the intra-uterine growth retardation and the risk of developing type 2 diabetes, obesity and cardiovascular disease postnatally has been well documented. The aim of this paper is to present an overview of the current knowledge of IUGR effects on development of hypertension and cardiovascular diseases, impact on insulin secretion and resistance, diabetes mellitus and metabolic syndrome. The influence of intrauterine growth retardation on predisposition to obesity and adipose dysfunction was also described.
宫内生长受限（IUGR）是围产期医学中的主要问题之一。IUGR是围产期死亡率和发病率的主要原因之一。已经描述了大量各种各样已确定的和可能的IUGR病因。目前尚无关于这种胎儿疾病有效治疗方法的数据。IUGR已被描述为与胎儿编程密切相关。胎儿编程是一个总体概念，它告诉我们在胚胎和胎儿发育过程中，环境事件如何塑造重要的生理参数。宫内生长受限与出生后发生2型糖尿病、肥胖症和心血管疾病的风险之间的联系已有充分记录。本文的目的是概述目前关于IUGR对高血压和心血管疾病发展的影响、对胰岛素分泌和抵抗的影响、糖尿病和代谢综合征的现有知识。还描述了宫内生长受限对肥胖易感性和脂肪功能障碍的影响。
