Xu Chunhua, Wang Wei, Wang Yuchao, Zhang Xiuwei, Yan Jun, Yu Like
Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, China.
Department of Respiratory Medicine, Nanjing Jiangning Hospital, Nanjing, Jiangsu, China.
Ann Clin Lab Sci. 2016 Winter;46(1):60-4.
To evaluate the clinical significance of angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) in lung cancer patients with solitary pulmonary nodule (SPN). The study enrolled 128 patients with malignant SPN, 60 patients with benign SPN, along with 40 healthy volunteers. Serum concentrations of Ang-2 and VEGF were measured by ELISA. Serum Ang-2 and VEGF levels in patients with malignant SPN were significantly higher than those in patients with benign SPN (p<0.01), and those in healthy volunteers (p<0.05). With a cutoff of 1504.8 pg/mL, the sensitivity and specificity of Ang-2 in differentiating between patients with malignant SPN and patients with benign SPN, and between patients with malignant SPN and healthy volunteers was 69.5 and 92.5%, and 80.5 and 97.5%, respectively. Additionally, higher levels of Ang-2 were associated with higher tumor stage (p<0.05). The levels of Ang-2 correlated with the VEGF level (p<0.01). In conclusion, measurement of serum Ang-2 might be a useful diagnostic marker for SPN patients.
评估血管生成素-2（Ang-2）和血管内皮生长因子（VEGF）在孤立性肺结节（SPN）肺癌患者中的临床意义。该研究纳入了128例恶性SPN患者、60例良性SPN患者以及40名健康志愿者。采用酶联免疫吸附测定法（ELISA）检测血清中Ang-2和VEGF的浓度。恶性SPN患者血清Ang-2和VEGF水平显著高于良性SPN患者（p<0.01），也高于健康志愿者（p<0.05）。以1504.8 pg/mL为临界值，Ang-2区分恶性SPN患者与良性SPN患者以及恶性SPN患者与健康志愿者的敏感性和特异性分别为69.5%和92.5%，以及80.5%和97.5%。此外，Ang-2水平越高与肿瘤分期越高相关（p<0.05）。Ang-2水平与VEGF水平相关（p<0.01）。总之，检测血清Ang-2可能是SPN患者有用的诊断标志物。
