来自阿氏夏至草的新型生物活性半日花烷二萜类化合物。

New bioactive labdane diterpenoids from Marrubium aschersonii.

作者信息

Hammami Saoussen, Li Zhenzhen, Huang Mingjie, El Mokni Ridha, Dhaouadi Hatem, Yin Sheng

机构信息

a Research Unit Applied Chemistry and Environment 13ES63, Faculty of Sciences of Monastir , Monastir University , Monastir , Tunisia.

b School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , China.

出版信息

Nat Prod Res. 2016 Oct;30(19):2142-8. doi: 10.1080/14786419.2016.1143828. Epub 2016 Feb 29.

DOI:10.1080/14786419.2016.1143828

PMID:26927415

Abstract

A phytochemical investigation of the ethanol extract of Marrubium aschersonii Magnus (Lamiaceae) collected from Tunisia led to the isolation and identification of two new labdane diterpenoids, marrubaschs A (1) and B (2), along with two known compounds (3 and 4). Their structures were elucidated by spectroscopic methods including HRESIMS and NMR techniques. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compound 2 exhibited weak inhibition of NO production with an IC50 value of 35 ± 1.0 μM.

摘要

对从突尼斯采集的绵毛水苏（唇形科）乙醇提取物进行植物化学研究，导致分离并鉴定出两种新的半日花烷二萜，绵毛水苏素A（1）和B（2），以及两种已知化合物（3和4）。通过包括高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）技术在内的光谱方法阐明了它们的结构。评估了所有化合物对脂多糖诱导的RAW 264.7巨噬细胞中一氧化氮（NO）产生的抑制作用。化合物2对NO产生表现出弱抑制作用，IC50值为35±1.0μM。