Haider Saida, Sadir Sadia, Naqvi Fizza, Batool Zehra, Tabassum Saiqa, Khaliq Saima, Anis Lubna, Sajid Irfan, Haleem Darakhshan J
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, 75270, Pakistan.
Department of Biochemistry, Jinnah University for Women, Karachi, 74600, Pakistan.
Metab Brain Dis. 2016 Aug;31(4):815-25. doi: 10.1007/s11011-016-9811-4. Epub 2016 Mar 1.
Magnesium (Mg) is the fourth most abundant biological mineral essential for good health. Neuroprotective, anxiolytic and antidepressant effects of magnesium following stress and brain injuries are well established. In present study, we analyzed the protective effects of magnesium in rats exposed to sub-chronic noise stress. Magnesium Chloride (MgCl2, 100 mg/kg) was administered intraperitoneally once daily for 15 days prior exposure to noise stress. Rats were exposed to noise stress for 4 h after administration of magnesium for 15 days. At the end of treatment behavioral alterations were assessed. Animals were decapitated following behavioral testing and the brains were dissected out for neurochemical estimations by HPLC-EC. Improvement in noise-induced memory deficits as assessed by novel object recognition (NOR) test and elevated plus maze (EPM) test was found in magnesium treated rats. This improvement in noise-induced behavioral deficits following treatment with magnesium may be attributed to a significant decrease (p < 0.01) in dopamine (DA) and serotonin (5-hydroxytryptamine; 5-HT) turnover as compared to control rats observed in present work. These results suggest that treatment with magnesium can attenuate the noise-induced deficits and may be used as a therapy against noise-induced neurodegeneration. Moreover an adequate amount of magnesium in daily diet may help to develop the ability to resist against or cope up with stressful conditions encountered in daily life.
镁（Mg）是第四种对身体健康至关重要且含量丰富的生物矿物质。镁在应激和脑损伤后的神经保护、抗焦虑和抗抑郁作用已得到充分证实。在本研究中，我们分析了镁对暴露于亚慢性噪声应激的大鼠的保护作用。在暴露于噪声应激前15天，每天腹腔注射一次氯化镁（MgCl2，100mg/kg）。在给予镁15天后，大鼠暴露于噪声应激4小时。在治疗结束时评估行为改变。行为测试后将动物断头，取出大脑用高效液相色谱-电化学法进行神经化学评估。在用镁处理的大鼠中，通过新物体识别（NOR）试验和高架十字迷宫（EPM）试验评估发现，噪声诱导的记忆缺陷有所改善。与本研究中观察到的对照大鼠相比，用镁治疗后噪声诱导的行为缺陷的这种改善可能归因于多巴胺（DA）和5-羟色胺（5-HT）周转率显著降低（p<0.01）。这些结果表明，镁治疗可以减轻噪声诱导的缺陷，并且可以用作对抗噪声诱导的神经退行性变的一种疗法。此外，日常饮食中适量的镁可能有助于培养抵抗或应对日常生活中遇到的压力状况的能力。
