Vlllarroel Julia, Álvarez Ana M, Chávez Ana, Cofré José, Galaz M Isabel, Ledesma Patricio, Peña Anamaría, Vizueta Eloisa, Wu Elba
Rev Chilena Infectol. 2015 Dec;32(6):672-6. doi: 10.4067/S0716-10182015000700009.
Pediatric HIV (+) patients have a 100 times greater risk of cancer than HIV (-) children.
To describe in Chilean HIV (+) children, cancer types, its appearance in relation to the stages of HIV disease and mortality.
A protocol was created to know some characteristics of these patients from the point of view of their HIV infection and cancer pathology.
Of 360 HIV (+) children confirmed by the Institute of Public Health to May 2014, 9 patients with neoplastic disease (2.5%) were diagnosed. All the children were on ART, had more than three years of evolution of HIV infection and were in moderate to severe clinical/immunological stages. Lymphoma was the most common cancer. Five children, has received therapy according to Programa Infantil Nacional de Drogas Antineoplásicas (PINDA). There was no interaction between cancer treatment and antiretroviral therapy. Mortality was 13.8 x 1000 (5 cases).
The incidence and type of neoplasia is consistent with the international literature, with less survival than HIV (+) children without tumors. The occurrence of cancer was observed in children with moderate to severe clinical and immunological compromise.
儿科HIV（+）患者患癌症的风险比HIV（-）儿童高100倍。
描述智利HIV（+）儿童的癌症类型、其与HIV疾病阶段的关系以及死亡率。
制定了一项方案，从HIV感染和癌症病理学角度了解这些患者的一些特征。
截至2014年5月，经公共卫生研究所确诊的360名HIV（+）儿童中，有9名患有肿瘤性疾病（2.5%）。所有儿童均接受抗逆转录病毒治疗，HIV感染病程超过三年，处于中度至重度临床/免疫阶段。淋巴瘤是最常见的癌症。5名儿童已根据国家儿童抗肿瘤药物计划（PINDA）接受治疗。癌症治疗与抗逆转录病毒治疗之间没有相互作用。死亡率为13.8/1000（5例）。
肿瘤的发生率和类型与国际文献一致，生存率低于无肿瘤的HIV（+）儿童。在临床和免疫功能中度至重度受损的儿童中观察到癌症的发生。
