Braamse Annemarie M J, van Turenhout Sietze T, Terhaar Sive Droste Jochim S, de Groot Gerrit H, van der Hulst René W M, Klemt-Kropp Michael, Kuiken Sjoerd D, Loffeld Ruud J L F, Uiterwaal M Tessa, Mulder Chris J J, Dekker Joost
aDepartment of Psychiatry and EMGO Institute for Health and Care Research Departments of bGastroenterology and Hepatology cRehabilitation Medicine, VU University Medical Center dDepartment of Gastroenterology and Hepatology, Sint Lucas Andreas Hospital, Amsterdam eDepartment of Gastroenterology and Hepatology, Rode Kruis Hospital, Beverwijk fDepartment of Gastroenterology and Hepatology, Kennemer Gasthuis, Haarlem gDepartment of Gastroenterology and Hepatology, Medical Center Alkmaar, Alkmaar hDepartment of Gastroenterology and Hepatology, Zaans Medical Center, Zaandam iDepartment of Gastroenterology and Hepatology, Spaarne Hospital, Hoofddorp, The Netherlands.
Eur J Gastroenterol Hepatol. 2016 Jul;28(7):831-5. doi: 10.1097/MEG.0000000000000615.
Up to 37% of colorectal cancer (CRC) survivors report depressive and anxiety symptoms. The identification of risk factors for depressive or anxiety symptoms might help focus supportive care resources on those patients most in need. The present study aims to explore which factors are associated with heightened anxiety or depression symptom severity.
In this cross-sectional study, individuals diagnosed with CRC 3.5 to 6 years ago completed questionnaires on sociodemographic information, medical comorbidities, anxiety symptoms (Beck Anxiety Inventory), and depressive symptoms (Inventory of Depressive Symptomatology). The general linear model analysis of covariance was used to identify factors associated with heightened anxiety or depressive symptom severity.
The sample included 91 CRC survivors, 40.7% women, mean age 69.1 years. A minority of CRC survivors had moderate (3.4%) or severe (2.3%) anxiety symptoms, and moderate (7.7%) or severe (0%) depressive symptoms. Shorter time since diagnosis and higher number of comorbid diseases were associated with higher anxiety symptom severity. Female sex and higher number of comorbid diseases were associated with higher depressive symptom severity.
From this explorative study, it follows that survivors with multiple comorbid diseases, shorter time since diagnosis, and female survivors might be at risk for higher anxiety and/or depressive symptom severity. Survivors with these characteristics might need extra monitoring.
高达37%的结直肠癌（CRC）幸存者报告有抑郁和焦虑症状。识别抑郁或焦虑症状的风险因素可能有助于将支持性护理资源集中于最需要的患者身上。本研究旨在探讨哪些因素与焦虑或抑郁症状严重程度增加相关。
在这项横断面研究中，3.5至6年前被诊断为CRC的个体完成了关于社会人口学信息、合并症、焦虑症状（贝克焦虑量表）和抑郁症状（抑郁症状量表）的问卷调查。采用协方差一般线性模型分析来识别与焦虑或抑郁症状严重程度增加相关的因素。
样本包括91名CRC幸存者，40.7%为女性，平均年龄69.1岁。少数CRC幸存者有中度（3.4%）或重度（2.3%）焦虑症状，以及中度（7.7%）或重度（0%）抑郁症状。诊断后时间较短和合并症数量较多与较高的焦虑症状严重程度相关。女性和合并症数量较多与较高的抑郁症状严重程度相关。
从这项探索性研究可以得出，患有多种合并症、诊断后时间较短的幸存者以及女性幸存者可能面临更高的焦虑和/或抑郁症状严重程度风险。具有这些特征的幸存者可能需要额外监测。
