Au Cheryl P, Sharma Neil S, McCluskey Peter, Ghabrial Raf
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Clin Exp Ophthalmol. 2016 Sep;44(7):550-554. doi: 10.1111/ceo.12733. Epub 2016 Mar 30.
Giant cell arteritis is a systemic inflammatory vasculitis of large-sized and medium-sized arteries. Superficial temporal artery biopsy of at least 20 mm has traditionally been the standard length for histopathology to accurately diagnose giant cell arteritis. Recent studies suggest than a post-fixation superficial temporal artery biopsy length of 7 to 10 mm is adequate for diagnosing giant cell arteritis.
This is a retrospective observational study.
The participants were all patients who underwent superficial temporal artery biopsy at Royal Prince Alfred Hospital, a large tertiary teaching hospital in Sydney, Australia, from 2008 to 2014.
Patients were identified using computerized hospital databases. Superficial temporal artery biopsy lengths were obtained from the histopathology reports.
We aimed to compare the superficial temporal artery biopsy lengths performed at a large tertiary hospital over the past 7 years, to those performed from 2000 to 2005, and to determine the frequency of diagnosis of giant cell arteritis over the two time periods.
There was a total of 96 superficial temporal artery biopsies performed from 2008 to 2014. The superficial temporal artery biopsy mean (standard deviation) length was 16.0(7.3) mm. This represented a significant (P = 0.015) increase in mean superficial temporal artery biopsy length when compared with a previous audit performed from 2000 to 2005 where the mean (standard deviation) superficial temporal artery biopsy was 11.7(6.2) mm. Of the 96 TABs, 20 (20.8%) were positive for giant cell arteritis, compared with a giant cell arteritis positivity rate of 20.4% for the previous audit period from 2000 to 2005.
There has been a significant improvement in the length of superficial temporal artery biopsy performed at a tertiary hospital. Despite the increase in superficial temporal artery biopsy lengths, the giant cell arteritis positivity rate has remained stable.
巨细胞动脉炎是一种累及大中型动脉的系统性炎症性血管炎。传统上，至少20毫米的颞浅动脉活检是组织病理学准确诊断巨细胞动脉炎的标准长度。最近的研究表明，固定后7至10毫米的颞浅动脉活检长度足以诊断巨细胞动脉炎。
这是一项回顾性观察研究。
参与者为2008年至2014年在澳大利亚悉尼一家大型三级教学医院——皇家阿尔弗雷德王子医院接受颞浅动脉活检的所有患者。
通过医院计算机数据库识别患者。从组织病理学报告中获取颞浅动脉活检长度。
我们旨在比较过去7年在一家大型三级医院进行的颞浅动脉活检长度与2000年至2005年期间的活检长度，并确定这两个时间段内巨细胞动脉炎的诊断频率。
2008年至2014年共进行了96次颞浅动脉活检。颞浅动脉活检的平均（标准差）长度为16.0（7.3）毫米。与2000年至2005年进行的前一次审计相比，这表明颞浅动脉活检平均长度有显著增加（P = 0.015），前一次审计中颞浅动脉活检的平均（标准差）长度为11.7（6.2）毫米。在96次活检中，20次（20.8%）巨细胞动脉炎呈阳性，而2000年至2005年的前一个审计期间巨细胞动脉炎阳性率为20.4%。
三级医院进行的颞浅动脉活检长度有显著改善。尽管颞浅动脉活检长度增加，但巨细胞动脉炎阳性率保持稳定。
