低剂量阿司匹林与妊娠：阿司匹林抵抗有多重要？
Low dose aspirin and pregnancy: how important is aspirin resistance?
机构信息
Centre for Women's Health Research, Institute of Translation Medicine, University of Liverpool, Liverpool, UK.
The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
出版信息
BJOG. 2016 Aug;123(9):1481-7. doi: 10.1111/1471-0528.13914. Epub 2016 Mar 1.
UNLABELLED
Antiplatelet agents are pivotal for prevention of coronary artery disease and cerebrovascular disease worldwide. Individual patient data meta-analysis indicates that low-dose aspirin causes a 10% risk reduction in pre-eclampsia for women at high individual risk. However, in the last 15 years it has emerged that a significant proportion of aspirin-treated individuals exhibit suboptimal platelet response, determined biochemically and clinically, termed 'aspirin non-responsiveness', 'aspirin resistance' and 'aspirin treatment failure'. More recently, investigation of aspirin responsiveness has begun in pregnant women. This review explores the history and clinical relevance of 'aspirin resistance' applied to high-risk obstetric populations.
TWEETABLE ABSTRACT
Is 'aspirin resistance' clinically relevant in high-risk obstetrics?
未加标签
抗血小板药物是预防全球冠状动脉疾病和脑血管疾病的关键。个体患者数据荟萃分析表明，对于高个体风险的女性，低剂量阿司匹林可降低 10%的子痫前期风险。然而，在过去的 15 年中，人们发现相当一部分接受阿司匹林治疗的个体表现出生物化学和临床上的血小板反应不理想，称为“阿司匹林无反应性”、“阿司匹林抵抗”和“阿司匹林治疗失败”。最近，人们开始在孕妇中研究阿司匹林的反应性。本综述探讨了“阿司匹林抵抗”应用于高危产科人群的历史和临床相关性。
推文摘要
在高危产科中，“阿司匹林抵抗”是否具有临床相关性？
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