Glatzer Markus, Elicin Olgun, Ramella Sara, Nestle Ursula, Putora Paul Martin
Dept of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Dept of Radiation Oncology, University Hospital Bern, Bern, Switzerland.
Eur Respir Rev. 2016 Mar;25(139):65-70. doi: 10.1183/16000617.0053-2015.
Definitive radiochemotherapy is the standard treatment for many patients with locally advanced nonsmall cell lung cancer (NSCLC). Treatment outcomes have improved over the last decades. Several treatment regimens have been shown effective and safe. This review summarises the results of significant studies between 1996 and 2015 on concomitant and sequential radiochemotherapy regimens and radiation dose per fraction. Beside therapy regimens, optimised radiotherapy planning is indispensable to improve outcome and minimise radiation-induced toxicity. An insight into the rationale of radiotherapy planning for stage III NSCLC is also provided.
确定性放化疗是许多局部晚期非小细胞肺癌（NSCLC）患者的标准治疗方法。在过去几十年中，治疗效果有所改善。几种治疗方案已被证明有效且安全。本综述总结了1996年至2015年间关于同步和序贯放化疗方案以及每次分割放疗剂量的重要研究结果。除了治疗方案外，优化放疗计划对于改善治疗效果和将放射诱导毒性降至最低是必不可少的。本文还深入探讨了III期NSCLC放疗计划的基本原理。
