Zagrodna A, Jóźków P, Mędraś M, Majda M, Słowińska-Lisowska M
Department of the Biological Basis of Sport, Wrocław University of Physical Education, Poland.
Lower Silesia Specialist Hospital, Tadeusz Marciniak Centre For Emergency Medicine, Poland.
Biol Sport. 2016 Mar;33(1):83-7. doi: 10.5604/20831862.1194125. Epub 2016 Feb 8.
Sclerostin is a protein secreted by osteocytes that acts as an inhibitor of bone formation. It has been shown that physical activity affects sclerostin concentration and thus bone remodelling. The aim of the study was to evaluate serum concentrations of sclerostin, selected bone turnover markers (PTH, P1NP), 25(OH)D3 and the intake of calcium and vitamin D in physically active versus sedentary men. A total of 59 healthy men aged 17-37 were enrolled in the study (43 athletes and 16 non-athletes). The mean sclerostin concentration in the group of athletes (A) was significantly higher than in non-athletes (NA) (35.3±8.9 vs 28.0±5.6 pmol·l(-1), p= 0.004). A compared with NA had higher concentrations of P1NP (145.6±77.5 vs 61.2±22.3 ng·ml(-1), p= <0.0001) and 25(OH)D3 (16.9±8.4 vs 10.3±4.3 ng·ml(-1), p= 0.004) and lower concentrations of PTH (25.8±8.3 vs 38.2±11.5 pg·ml(-1), p= <0.0001). Vitamin D deficiency was found in 77% of A and 100% of NA. A and NA had similar daily energy intake. They did not differ as to the intake of calcium and vitamin D. We observed a negative correlation between the serum concentrations of sclerostin and calcium in the studied subjects. Our results suggest that regular, long-lasting physical training may be associated with higher concentration of sclerostin. It seems that increased sclerostin is not related to other bone turnover markers (PTH, P1NP).
硬化素是一种由骨细胞分泌的蛋白质，它作为骨形成的抑制剂发挥作用。研究表明，体育活动会影响硬化素浓度，进而影响骨重塑。本研究的目的是评估身体活跃的男性与久坐不动的男性血清中硬化素、选定的骨转换标志物（甲状旁腺激素、I型前胶原氨基端前肽）、25-羟基维生素D3（25(OH)D3）的浓度以及钙和维生素D的摄入量。共有59名年龄在17至37岁的健康男性参与了该研究（43名运动员和16名非运动员）。运动员组（A）的平均硬化素浓度显著高于非运动员组（NA）（35.3±8.9对28.0±5.6 pmol·l(-1)，p = 0.004）。与NA相比，A组的I型前胶原氨基端前肽（P1NP）浓度更高（145.6±77.5对61.2±22.3 ng·ml(-1)，p = <0.0001），25-羟基维生素D3（25(OH)D3）浓度更高（16.9±8.4对10.3±4.3 ng·ml(-1)，p = 0.004），而甲状旁腺激素（PTH）浓度更低（25.8±8.3对38.2±11.5 pg·ml(-1)，p = <0.0001）。77%的A组和100%的NA组存在维生素D缺乏。A组和NA组的每日能量摄入量相似。他们在钙和维生素D的摄入量方面没有差异。我们观察到在研究对象中，硬化素血清浓度与钙之间存在负相关。我们的结果表明，规律、持久的体育锻炼可能与更高的硬化素浓度相关。似乎硬化素升高与其他骨转换标志物（PTH、P1NP）无关。
