Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging (B.D.-H., S.S.H., L.C., N.J.P.), Tufts University, and Division of Endocrinology, Diabetes, and Metabolism (B.D.-H., L.C.), Tufts Medical Center, Boston, Massachusetts 02111.
J Clin Endocrinol Metab. 2014 Jan;99(1):E149-52. doi: 10.1210/jc.2013-3148. Epub 2013 Dec 20.
To establish the clinical utility of serum sclerostin levels, it is important to know whether there is seasonal variation in the measurements.
This study was done to determine whether serum sclerostin levels vary by season in healthy older men and women.
Serum sclerostin levels were measured in archived serum of 314 healthy men and women aged 65 years and older and examined for seasonal variation. Several factors known to vary by season and previously reported to be associated with serum sclerostin levels, including serum osteocalcin, physical activity, and serum PTH levels, were also measured in these subjects. Sex did not modify the association of season with sclerostin, so the men and women were analyzed together.
Serum sclerostin levels varied significantly by season (P < .001, after adjustment for sex). Sclerostin levels in the wintertime were 20% higher than the all-year mean, the levels gradually declined through the spring and summer, and by the fall, they were 20% below the all-year mean. Adjustment for serum osteocalcin, physical activity, and serum PTH did not alter the seasonal means. Seasonal differences in serum osteocalcin, physical activity, and serum PTH were not statistically significant.
This study documents marked seasonal variation in serum sclerostin levels. It is important to recognize this source of biological variability when considering the potential clinical utility of sclerostin measurements.
为了确定血清骨硬化蛋白水平的临床实用性，了解其测量值是否存在季节性变化非常重要。
本研究旨在确定健康老年男女的血清骨硬化蛋白水平是否存在季节性变化。
检测了 314 名年龄在 65 岁及以上的健康男女的存档血清中的血清骨硬化蛋白水平，并检查了其季节性变化。还测量了这些受试者中已知随季节变化且先前与血清骨硬化蛋白水平相关的几个因素，包括血清骨钙素、身体活动和血清甲状旁腺激素水平。性别并未改变季节与骨硬化蛋白之间的关联，因此将男性和女性一起进行分析。
血清骨硬化蛋白水平随季节显著变化（P<0.001，调整性别后）。冬季的骨硬化蛋白水平比全年平均值高 20%，春季和夏季逐渐下降，到秋季时比全年平均值低 20%。调整血清骨钙素、身体活动和血清甲状旁腺激素水平后，季节性平均值并未改变。血清骨钙素、身体活动和血清甲状旁腺激素的季节性差异无统计学意义。
本研究记录了血清骨硬化蛋白水平的显著季节性变化。在考虑骨硬化蛋白测量值的潜在临床实用性时，必须认识到这种生物变异性的来源。
