McCarthy T L, Centrella M, Canalis E
Department of Medicine, Saint Francis Hospital & Medical Center, Hartford, CT.
Connect Tissue Res. 1989;20(1-4):277-82. doi: 10.3109/03008208909023897.
Bone is not only a rich source of a diverse group of growth factors, but is also a very responsive tissue to such growth promoting agents. IGF-I and IGF-II are reported to be synthesized and retained in bone. While both IGF-I and IGF-II stimulate DNA, collagen, and noncollagenous protein synthesis in cultured calvariae, these explant cultures have quantitative differential sensitivities to these IGF's. In addition to the observed increase in collagen synthesis, collagen degradation decreased in calvariae treated with IGF-I or IGF-II.
骨不仅是多种生长因子的丰富来源，而且是对这类生长促进剂反应非常灵敏的组织。据报道，胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子-II（IGF-II）在骨中合成并留存。虽然IGF-I和IGF-II都能刺激培养的颅骨中的DNA、胶原蛋白和非胶原蛋白的合成，但这些外植体培养物对这些胰岛素样生长因子具有不同的定量敏感性。除了观察到胶原蛋白合成增加外，用IGF-I或IGF-II处理的颅骨中胶原蛋白降解也减少了。
