Fernandes Gabriela, Yang Shuying
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York , Buffalo, NY, USA.
Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA; Developmental Genomics Group, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Anatomy & Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bone Res. 2016 Dec 13;4:16036. doi: 10.1038/boneres.2016.36. eCollection 2016.
Presently, there is a high paucity of bone grafts in the United States and worldwide. Regenerating bone is of prime concern due to the current demand of bone grafts and the increasing number of diseases causing bone loss. Autogenous bone is the present gold standard of bone regeneration. However, disadvantages like donor site morbidity and its decreased availability limit its use. Even allografts and synthetic grafting materials have their own limitations. As certain specific stem cells can be directed to differentiate into an osteoblastic lineage in the presence of growth factors (GFs), it makes stem cells the ideal agents for bone regeneration. Furthermore, platelet-rich plasma (PRP), which can be easily isolated from whole blood, is often used for bone regeneration, wound healing and bone defect repair. When stem cells are combined with PRP in the presence of GFs, they are able to promote osteogenesis. This review provides in-depth knowledge regarding the use of stem cells and PRP , and their application in clinical studies in the future.
目前，美国乃至全球范围内骨移植材料都极为匮乏。鉴于当前对骨移植的需求以及导致骨质流失的疾病数量不断增加，骨再生成为首要关注的问题。自体骨是目前骨再生的金标准。然而，诸如供体部位发病风险及其可用性降低等缺点限制了其应用。即使是同种异体骨和合成移植材料也有各自的局限性。由于某些特定的干细胞在生长因子（GFs）存在的情况下可被诱导分化为成骨细胞谱系，这使得干细胞成为骨再生的理想介质。此外，富含血小板血浆（PRP）可轻易从全血中分离出来，常用于骨再生、伤口愈合和骨缺损修复。当干细胞与PRP在生长因子存在的情况下结合时，它们能够促进成骨作用。本综述提供了有关干细胞和PRP的使用及其在未来临床研究中的应用的深入知识。
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