白内障患者房水中的沉默信息调节因子T1
Silent information regulator T1 in aqueous humor of patients with cataract.
作者信息
Kondo Aki, Goto Mari, Mimura Tatsuya, Matsubara Masao
机构信息
Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
出版信息
Clin Ophthalmol. 2016 Feb 15;10:307-12. doi: 10.2147/OPTH.S100213. eCollection 2016.
PURPOSE
Silent information regulator T1 (SIRT1), a member of the sirtuin family, has a preventive role in various ocular diseases. We evaluated the relations between the aqueous humor level of SIRT1 and age, sex, systemic diseases, the severity of lens opacity, and other factors.
SETTING
This study was conducted at a university teaching hospital in Tokyo, Japan.
DESIGN
This study was designed based on the consecutive case series.
METHODS
Aqueous humor samples were obtained from 29 eyes of the 21 consecutive patients undergoing surgery for age-related cataract (ARC). SIRT1 levels were determined by enzyme-linked immunosorbent assay.
RESULTS
Aqueous humor levels of SIRT1 showed a positive correlation with visual acuity (logarithm of the minimum angle of resolution) and with the severity of nuclear cataract (r=0.32 and 0.30, respectively, P<0.05). However, only visual acuity was correlated with SIRT1 according to the stepwise multiple regression analysis (P<0.05).
CONCLUSION
These findings suggest that SIRT1 may have an effect on the formation of ARC, acting as a defensive factor against ARC.
目的
沉默信息调节因子T1（SIRT1）是sirtuin家族的一员，在多种眼部疾病中具有预防作用。我们评估了房水中SIRT1水平与年龄、性别、全身疾病、晶状体混浊严重程度及其他因素之间的关系。
地点
本研究在日本东京的一所大学教学医院进行。
设计
本研究基于连续病例系列设计。
方法
从21例连续接受年龄相关性白内障（ARC）手术患者的29只眼中获取房水样本。通过酶联免疫吸附测定法测定SIRT1水平。
结果
房水中SIRT1水平与视力（最小分辨角对数）和核性白内障严重程度呈正相关（分别为r = 0.32和0.30，P < 0.05）。然而，根据逐步多元回归分析，只有视力与SIRT1相关（P < 0.05）。
结论
这些发现表明SIRT1可能对ARC的形成有影响，作为ARC的防御因子发挥作用。
Zotero 插件