鼻中隔恶性黑色素瘤是一种罕见肿瘤，发生在一名54岁曾接受遗传性视网膜母细胞瘤治疗的患者身上。

Malignant melanoma of the nasal septum, a rare tumor, occurring in a 54-year-old patient after hereditary retinoblastoma treatment.

作者信息

Djiguimdé Windinmanégdé Pierre, Diomandé Ibrahim Abib, Bonnin Nicolas, Saroul Nicolas, Touré Abdoulaye, Sanou Jérôme, Sankara Paté, Russier Marc, Gilain Laurent, Ahnoux-Zabsonré Ahgbatouhabéba, Meda Nonfounikoun, Bacin Franck

机构信息

Ophthalmology Department, University Hospital Yalgado Ouédraogo, Ouagadougou, Burkina Faso.

Ophthalmology Department, University Hospital of Bouaké, University Alassane Ouattara, Bouaké, Cote d'Ivoire.

出版信息

Int Med Case Rep J. 2016 Feb 9;9:25-8. doi: 10.2147/IMCRJ.S88494. eCollection 2016.

DOI:10.2147/IMCRJ.S88494

PMID:26929670

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4755470/

Abstract

The authors report a case of a malignant melanoma of the nasal cavity that is a rare tumor and very aggressive, constituting 1% of all melanomas. It appeared in a patient 54 years after he was treated for a hereditary retinoblastoma. Its symptoms are nonspecific, and often marked by epistaxis. Its diagnosis is histological, supported by immunohistochemistry. Its prognosis is often unfavorable, and characterized by the occurrence of metastases and recurrences. Because of the risk of secondary cancer that exists in any survivor of hereditary retinoblastoma, we must think of possible mucosal melanoma of the nasal sinus in these patients in cases of chronic epistaxis. The prognosis of this tumor depends on its early diagnosis and surgical treatment.

摘要

作者报告了一例鼻腔恶性黑色素瘤病例，该肿瘤罕见且极具侵袭性，占所有黑色素瘤的1%。它出现在一名曾接受遗传性视网膜母细胞瘤治疗54年后的患者身上。其症状不具特异性，常以鼻出血为特征。其诊断依靠组织学检查，并由免疫组织化学辅助。其预后通常不佳，以转移和复发为特点。由于遗传性视网膜母细胞瘤的任何幸存者都存在继发癌症的风险，对于这些患者，若出现慢性鼻出血，我们必须考虑鼻窦黏膜黑色素瘤的可能性。该肿瘤的预后取决于早期诊断和手术治疗。