Nikniaz Zeinab, Mahdavi Reza, Nikniaz Leila, Ebrahimi Aliasghar, Ostadrahimi Alireza
a Liver and Gastrointestinal Diseases Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
b Nutrition Research Centre , Tabriz University of Medical Sciences , Tabriz , Iran.
J Diet Suppl. 2016 Nov;13(6):595-606. doi: 10.3109/19390211.2016.1150933. Epub 2016 Mar 1.
In the present randomized double-blinded placebo-controlled study, the effect of Elaeagnus angustifolia L. (EA) whole fruit and medulla powders on anthropometric indices, serum lipid profile, and atherogenic indices in females with knee osteoarthritis (OA) was investigated. Ninety females with mild to moderate knee osteoarthritis were randomly assigned to one of three groups-medulla powder, whole fruit powder, or placebo. The subjects received 15 g/day of medulla powder of EA, whole fruit powder of EA, or placebo. Lipid profile, weight, and dietary intake were measured at baseline and at the end of the study. Body mass index and atherogenic indices were calculated. Statistical analysis was performed using SPSS version 13.0, and Paired t tests, analysis of variance (ANOVA), analysis of covariance (ANCOVA), and the Tukey post hoc test were used to compare within-group and between-group values. After 8 weeks of supplementations, compared with the baseline, significant reductions in total cholesterol (TC), low density lipoprotein/high density lipoprotein (LDL/HDL), and TC/HDL ratios were observed in the two supplemented groups; however, the reduction of these values was not statistically significant in the placebo group. There were significant differences between the patients who received medulla powder and placebo group in the case of changes in TC/HDL and LDL/HDL ratios (p < .001). However, no significant differences were found between the two supplemented groups in the case of changes in studied values (p > .05). Generally, whole fruit and medulla powders of Elaeagnus angustifolia L. had positive effects, especially in decreasing total cholesterol and atherogenic indices in females with knee OA.
在本随机双盲安慰剂对照研究中，考察了沙棘全果及髓质粉对女性膝骨关节炎（OA）患者人体测量指标、血脂谱及致动脉粥样硬化指数的影响。90例轻度至中度膝骨关节炎女性被随机分为三组之一：髓质粉组、全果粉组或安慰剂组。受试者每天服用15克沙棘髓质粉、全果粉或安慰剂。在基线期和研究结束时测量血脂谱、体重和饮食摄入量。计算体重指数和致动脉粥样硬化指数。使用SPSS 13.0版进行统计分析，采用配对t检验、方差分析（ANOVA）、协方差分析（ANCOVA）以及Tukey事后检验来比较组内和组间数值。补充8周后，与基线相比，两个补充组的总胆固醇（TC）、低密度脂蛋白/高密度脂蛋白（LDL/HDL）以及TC/HDL比值均显著降低；然而，安慰剂组这些数值的降低无统计学意义。在TC/HDL和LDL/HDL比值变化方面，接受髓质粉的患者与安慰剂组之间存在显著差异（p < .001）。然而，在研究数值变化方面，两个补充组之间未发现显著差异（p > .05）。总体而言，沙棘全果及髓质粉具有积极作用，尤其是在降低女性膝骨关节炎患者的总胆固醇和致动脉粥样硬化指数方面。
