Karimifar Mansoor, Soltani Rasool, Hajhashemi Valiollah, Sarrafchi Sara
Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Clin Rheumatol. 2017 Aug;36(8):1849-1853. doi: 10.1007/s10067-017-3603-z. Epub 2017 Mar 27.
Osteoarthritis (OA) is one of the most common articular disorders. Many patients do not respond to acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), the mainstay of pharmacotherapy for knee OA. The plants Elaeagnus angustifolia and Boswellia thurifera have anti-inflammatory and analgesic properties. This study aimed to evaluate the effect of E. angustifolia alone and in combination with B. thurifera compared with ibuprofen in patients with knee osteoarthritis. In a randomized double-blind controlled clinical trial, 75 patients with knee OA were randomly and equally assigned to one of three groups Elaeagnus (n = 23), Elaeagnus/Boswellia (n = 26), and ibuprofen (n = 26) to receive the capsules of Elaeagnus, Elaeagnus/Boswellia, and ibuprofen, respectively, three times daily with meals for 4 weeks. Pain severity based on VAS (visual analog scale, 0 to 10 scale) and the scores of LPFI (Lequesne Pain and Function Index) and PGA (patient global assessment) were determined pre- and post-intervention for all patients. All interventions had significant lowering effects on VAS, LPFI, and PGA scores (P < 0.001 for all parameters) with no significant difference between groups in terms of effects on all evaluated parameters. Consumption of E. angustifolia fruit extract either alone or in combination with Boswellia oleo-gum resin extract could decrease pain and improve function in patients with knee osteoarthritis comparable to ibuprofen.
骨关节炎（OA）是最常见的关节疾病之一。许多患者对乙酰氨基酚和非甾体抗炎药（NSAIDs）无反应，而这两种药物是膝关节OA药物治疗的主要手段。沙枣和乳香具有抗炎和镇痛特性。本研究旨在评估单独使用沙枣以及沙枣与乳香联合使用相比布洛芬对膝关节骨关节炎患者的疗效。在一项随机双盲对照临床试验中，75例膝关节OA患者被随机且平均分为三组：沙枣组（n = 23）、沙枣/乳香组（n = 26）和布洛芬组（n = 26），分别接受沙枣胶囊、沙枣/乳香胶囊和布洛芬胶囊治疗，每日三次，与餐同服，持续4周。在干预前后测定所有患者基于视觉模拟量表（VAS，0至10分）的疼痛严重程度、Lequesne疼痛和功能指数（LPFI）评分以及患者整体评估（PGA）评分。所有干预措施对VAS、LPFI和PGA评分均有显著降低作用（所有参数P < 0.001），在对所有评估参数的影响方面，各组之间无显著差异。单独食用沙枣果实提取物或与乳香油树脂提取物联合食用，在减轻膝关节骨关节炎患者疼痛和改善功能方面与布洛芬相当。
