Pandya Hardik J, Park Kihan, Chen Wenjin, Goodell Lauri A, Foran David J, Desai Jaydev P
IEEE Trans Biomed Eng. 2016 Jul;63(7):1347-53. doi: 10.1109/TBME.2016.2535364. Epub 2016 Feb 26.
The objective of this study is to design and develop a portable tool consisting of a disposable biochip for measuring electrothermomechanical (ETM) properties of breast tissue.
A biochip integrated with a microheater, force sensors, and electrical sensors is fabricated using microtechnology. The sensor covers the area of 2 mm and the biochip is 10 mm in diameter. A portable tool capable of holding tissue and biochip is fabricated using 3-D printing. Invasive ductal carcinoma and normal tissue blocks are selected from cancer tissue bank in Biospecimen Repository Service at Rutgers Cancer Institute of New Jersey. The ETM properties of the normal and cancerous breast tissues (3-mm thickness and 2-mm diameter) are measured by indenting the tissue placed on the biochip integrated inside the 3-D printed tool.
Integrating microengineered biochip and 3-D printing, we have developed a portable cancer diagnosis device. Using this device, we have shown a statistically significant difference between cancerous and normal breast tissues in mechanical stiffness, electrical resistivity, and thermal conductivity.
The developed cancer diagnosis device is capable of simultaneous ETM measurements of breast tissue specimens and can be a potential candidate for delineating normal and cancerous breast tissue cores.
The portable cancer diagnosis tool could potentially provide a deterministic and quantitative information about the breast tissue characteristics, as well as the onset and disease progression of the tissues. The tool can be potentially used for other tissue-related cancers.
本研究的目的是设计并开发一种便携式工具，该工具包含一个用于测量乳腺组织电热机械（ETM）特性的一次性生物芯片。
利用微技术制造一种集成了微型加热器、力传感器和电传感器的生物芯片。传感器覆盖面积为2毫米，生物芯片直径为10毫米。使用3D打印制造一种能够容纳组织和生物芯片的便携式工具。从新泽西州罗格斯癌症研究所生物样本库服务中心的癌症组织库中选取浸润性导管癌和正常组织块。通过对放置在3D打印工具内集成的生物芯片上的组织进行压痕操作，测量正常和癌性乳腺组织（厚度3毫米、直径2毫米）的ETM特性。
通过整合微工程生物芯片和3D打印技术，我们开发出了一种便携式癌症诊断设备。使用该设备，我们发现癌性和正常乳腺组织在机械刚度、电阻率和热导率方面存在统计学上的显著差异。
所开发的癌症诊断设备能够同时对乳腺组织样本进行ETM测量，并且可能成为区分正常和癌性乳腺组织核心的潜在候选工具。
这种便携式癌症诊断工具可能提供有关乳腺组织特征以及组织发病和疾病进展的确定性和定量信息。该工具可能用于其他与组织相关的癌症。
