[前列腺癌中Gleason评分的可重复性]

[Reproducibility of Gleason scores in prostate cancer].

作者信息

He Hui-jie, Wang Gong-wei

出版信息

Zhonghua Nan Ke Xue. 2016 Jan;22(1):37-41.

PMID:26931024

Abstract

OBJECTIVE

To investigate the reproducibility of Gleason scores for prostate cancer.

METHODS

Based on the revised Gleason Scoring System of the International Society of Urological Pathology ( ISUP) , we analyzed the reproducibility and difference of Gleason scores in 49 cases of prostate cancer using the methods of combination and grouping.

RESULTS

The total reproducibility of Gleason scores among 15 pathologists was good (κ = 0.642), 62.2% by the combination method, the highest in Gleason 5 + 5 (81.2%) and 5 +4 (73.3%), then in Gleason 4 + 4 (67.5%), 3 + 3 (64.0%), 4 +3 (61.3%), and 3 + 4 (44.0%), and the lowest in Gleason 4 + 5 (38.9%) and 3 + 5 (33.3%). The total reproducibility of Gleason scores by the grouping method was 71.4%, the highest in Gleason 9-10 (84.9%) , then in Gleason 7 (76.7%) and 6 (64.0%), and the lowest in Gleason 8 (60.7%).

CONCLUSION

The reproducibility of Gleason scores remains to be further improved in prostate cancer, mainly concerning the understanding of Gleason 3 and 4 carcinoma.

摘要

目的

探讨前列腺癌Gleason评分的可重复性。

方法

基于国际泌尿病理学会（ISUP）修订的Gleason评分系统，采用合并和分组的方法分析49例前列腺癌Gleason评分的可重复性及差异。

结果

15位病理学家之间Gleason评分的总体可重复性良好（κ = 0.642），合并法为62.2%，在Gleason 5 + 5（81.2%）和5 + 4（73.3%）中最高，其次是Gleason 4 + 4（67.5%）、3 + 3（64.0%）、4 + 3（61.3%）和3 + 4（44.0%），在Gleason 4 + 5（38.9%）和3 + 5（33.3%）中最低。分组法Gleason评分的总体可重复性为71.4%，在Gleason 9 - 10（84.9%）中最高，其次是Gleason 7（76.7%）和6（64.0%），在Gleason 8（60.7%）中最低。