Montironi Rodolfo, Santoni Matteo, Mazzucchelli Roberta, Burattini Luciano, Berardi Rossana, Galosi Andrea B, Cheng Liang, Lopez-Beltran Antonio, Briganti Alberto, Montorsi Francesco, Scarpelli Marina
a Section of Pathological Anatomy , Polytechnic University of the Marche Region, School of Medicine, United Hospitals , Ancona , Italy.
b Clinica di Oncologia Medica, AOU Ospedali Riuniti , Polytechnic University of the Marche Region , Ancona , Italy.
Expert Rev Anticancer Ther. 2016;16(4):433-40. doi: 10.1586/14737140.2016.1160780.
The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.
格里森分级系统是由唐纳德·F·格里森博士在20世纪60年代末开发的。由于前列腺腺癌（PAC）检测和治疗的变化、用于更好地描述前列腺病理特征的新技术、随后描述的PAC变体以及将各种形态学模式与预后相关联的更多数据，格里森分级系统在外科病理学中的应用发生了重大变化。2005年首次以及最近在2014年，召开了共识会议以更新PAC分级。在此，我们回顾PAC分级从原始系统开始的连续变化，重点关注最新的预后分级分组。
