Bonifacio Guendalina, Zamboni Giovanna
Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Italy.
Postgrad Med J. 2016 Jun;92(1088):333-40. doi: 10.1136/postgradmedj-2015-133759. Epub 2016 Mar 1.
The introduction of MRI and positron emission tomography (PET) brain imaging has contributed significantly to the understanding of different dementia syndromes. Over the past 20 years these imaging techniques have been increasingly used for clinical characterisation and differential diagnosis, and to provide insight into the effects on functional capacity of the brain, patterns of spatial distribution of different dementia syndromes and their natural history and evolution over time. Brain imaging is also increasingly used in clinical trials, as part of inclusion criteria and/or as a surrogate outcome measure. Here we review all the relatively specific findings that can be identified with different MRI and PET techniques in each of the most frequent dementing disorders.
磁共振成像（MRI）和正电子发射断层扫描（PET）脑成像技术的引入，极大地促进了人们对不同痴呆综合征的理解。在过去20年中，这些成像技术越来越多地用于临床特征描述和鉴别诊断，并有助于深入了解大脑功能能力所受的影响、不同痴呆综合征的空间分布模式及其自然病史和随时间的演变。脑成像也越来越多地用于临床试验，作为纳入标准的一部分和/或作为替代结局指标。在此，我们回顾在每种最常见的痴呆性疾病中，通过不同的MRI和PET技术能够识别出的所有相对特异的发现。
