Thompson E W, Martin M B, Saceda M, Clarke R, Brunner N, Lippman M E, Dickson R B
Vincent T Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C.
Horm Res. 1989;32 Suppl 1:242-9. doi: 10.1159/000181356.
The current understanding of the regulation of breast cancer cell proliferation and invasiveness by hormones and growth factors is reviewed. It has been shown that polypeptide growth factors are involved in hormone-independent breast cancer, and are sometimes oestrogen-regulated in hormone-responsive models. Basement-membrane invasiveness, relating to the metastatic potential of these cells, is also stimulated by oestrogen in hormone-dependent models, elevated in hormone-independent models, and is growth factor sensitive. Further understanding of the differential effects of growth factors on breast cancer cell proliferation and invasiveness should facilitate better therapeutic exploitation of regulation at this level.
本文综述了目前关于激素和生长因子对乳腺癌细胞增殖及侵袭性调控的理解。研究表明，多肽生长因子参与激素非依赖性乳腺癌，且在激素反应性模型中有时受雌激素调控。在激素依赖性模型中，与这些细胞转移潜能相关的基底膜侵袭性也受雌激素刺激；在激素非依赖性模型中则升高，并且对生长因子敏感。进一步了解生长因子对乳腺癌细胞增殖和侵袭性的不同影响，应有助于在这一层面对调控进行更好的治疗性应用。
