King R J
Hormone Biochemistry Laboratory, Imperial Cancer Research Fund, London, UK.
Horm Res. 1989;32 Suppl 1:254-6. doi: 10.1159/000181358.
Both steroid-responsive and unresponsive cancers can be identified at first presentation. Endocrine treatment produces remission that, however, is invariably followed by relapse. The role of steroids in the genesis of the pathways involved in producing a steroid-unresponsive cancer is discussed, as are its clinical implications using data from mammary tumour cell lines.
在首次就诊时，类固醇反应性和无反应性癌症均可被识别。内分泌治疗可产生缓解，但缓解后 invariably 会复发。本文讨论了类固醇在导致类固醇无反应性癌症的相关通路发生过程中的作用，并利用乳腺肿瘤细胞系的数据探讨了其临床意义。
