Arondi Sabrina, Valsecchi Alberto, Borghesi Andrea, Monti Stefano
Specialization School in Respiratory Diseases, Department of Medical and Surgical Sciences, Italy.
Division of Diagnostic Radiology II, Department of Medical and Surgical Specialties, Radiologic Sciences and Public Health, University of Brescia, Italy.
Ann Thorac Med. 2016 Jan-Mar;11(1):79-81. doi: 10.4103/1817-1737.164301.
Sarcoidosis is a common disease that involve almost constantly the lung. Usually the onset is insidious, and symptoms are slowly ingravescent. Very rarely, as in the case here reported, sarcoidosis can cause an acute respiratory failure with acute respiratory distress syndrome (ARDS). A 20-year-old girl from Pakistan presented for acute fatigue, fever, and cough with a chest X-ray displayed the micronodular interstitial disease. Despite of anti-tuberculosis therapy, ARDS developed in a few days requiring continuous positive airway pressure treatment. Examinations on transbronchial specimens obtained by bronchoscopy permitted to reach the diagnosis of sarcoidosis and steroid therapy improved rapidly clinical conditions. This is the first case report reported in Europe that confirms the rare onset of sarcoidosis as ARDS. Steroid therapy allows to cure rapidly this severe complication.
结节病是一种常见疾病，几乎总是累及肺部。通常起病隐匿，症状逐渐加重。非常罕见的是，如本报告所述的病例，结节病可导致急性呼吸衰竭伴急性呼吸窘迫综合征（ARDS）。一名来自巴基斯坦的20岁女孩因急性疲劳、发热和咳嗽就诊，胸部X线显示为微小结节性间质性疾病。尽管进行了抗结核治疗，但数天内仍发展为ARDS，需要持续气道正压通气治疗。通过支气管镜检查获取的经支气管标本检查得以确诊结节病，类固醇治疗迅速改善了临床状况。这是欧洲报道的首例证实结节病罕见地以ARDS形式起病的病例报告。类固醇治疗能够迅速治愈这种严重并发症。
