Cuccione Elisa, Padovano Giada, Versace Alessandro, Ferrarese Carlo, Beretta Simone
Laboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy ; PhD Programme in Neuroscience, University of Milano Bicocca, Monza, Italy.
Laboratory of Experimental Stroke Research, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy.
Exp Transl Stroke Med. 2016 Mar 1;8:2. doi: 10.1186/s13231-016-0015-0. eCollection 2016.
Cerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several methods may be used for assessing cerebral collaterals in the acute phase of ischemic stroke in humans and rodents, they are generally underutilized. Experimental stroke models may play a unique role in understanding the adaptive response of cerebral collaterals during ischemia and their potential for therapeutic modulation. The systematic assessment of collateral perfusion in experimental stroke models may be used as a "stratification factor" in multiple regression analysis of neuroprotection studies, in order to control the within-group variability. Exploring the modulatory mechanisms of cerebral collaterals in stroke models may promote the translational development of therapeutic strategies for increasing collateral flow and directly compare them in term of efficacy, safety and feasibility. Collateral therapeutics may have a role in the hyperacute (even pre-hospital) phase of ischemic stroke, prior to recanalization therapies.
脑侧支循环是一个辅助血管网络，在动脉闭塞后动态募集，是缺血性卒中预后的一个重要决定因素。虽然有几种方法可用于评估人类和啮齿动物缺血性卒中急性期的脑侧支，但这些方法普遍未得到充分利用。实验性卒中模型在理解缺血期间脑侧支的适应性反应及其治疗调节潜力方面可能发挥独特作用。对实验性卒中模型中的侧支灌注进行系统评估，可作为神经保护研究多元回归分析中的一个“分层因素”，以控制组内变异性。探索卒中模型中脑侧支的调节机制，可能会促进增加侧支血流治疗策略的转化发展，并在疗效、安全性和可行性方面对其进行直接比较。侧支治疗可能在缺血性卒中的超急性期（甚至院前）、再通治疗之前发挥作用。
