Polo Valentina, Pasello Giulia, Frega Stefano, Favaretto Adolfo, Koussis Haralabos, Conte Pierfranco, Bonanno Laura
Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.
Department of Surgery, Oncology and Gastroenterology, Università degli Studi di Padova, Padova, Italy.
Oncotarget. 2016 May 3;7(18):25050-63. doi: 10.18632/oncotarget.7732.
Squamous cell carcinomas of the lung and of the head and neck district share strong association with smoking habits and are characterized by smoke-related genetic alterations. Driver mutations have been identified in small percentage of lung squamous cell carcinoma. In parallel, squamous head and neck tumors are classified according to the HPV positivity, thus identifying two different clinical and molecular subgroups of disease.This review depicts different molecular portraits and potential clinical application in the field of targeted therapy, immunotherapy and chemotherapy personalization.
肺癌以及头颈部区域的鳞状细胞癌都与吸烟习惯密切相关，并且具有与吸烟相关的基因改变特征。在一小部分肺鳞状细胞癌中已鉴定出驱动突变。与此同时，头颈部鳞状肿瘤根据人乳头瘤病毒（HPV）的阳性情况进行分类，从而确定了该疾病的两个不同临床和分子亚组。本综述描绘了不同的分子特征以及在靶向治疗、免疫治疗和化疗个体化领域的潜在临床应用。
