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亚甲蓝用于治疗血管麻痹综合征后发生的血清素综合征。

Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome.

作者信息

Hencken Laura, To Long, Ly Nancy, Morgan Jeffrey A

机构信息

Department of Pharmacy Services, Henry Ford Hospital, Detroit, Michigan.

Department of Cardiology, Henry Ford Hospital, Detroit, Michigan.

出版信息

J Card Surg. 2016 Apr;31(4):208-10. doi: 10.1111/jocs.12705. Epub 2016 Mar 2.

DOI:10.1111/jocs.12705
PMID:26934199
Abstract

Methylene blue (MB) has been used for additional blood pressure support in patients who develop severe, refractory vasoplegia; however, MB can induce serotonin syndrome, especially when used in conjunction with other serotonergic agents. We describe a case of serotonin syndrome in a patient who received MB for vasoplegic syndrome after left ventricular assist device implantation and discuss its presentation and management.

摘要

亚甲蓝（MB）已被用于对发生严重难治性血管麻痹的患者进行额外的血压支持；然而，亚甲蓝可诱发血清素综合征，尤其是在与其他血清素能药物联合使用时。我们描述了一例在植入左心室辅助装置后因血管麻痹综合征接受亚甲蓝治疗的患者发生血清素综合征的病例，并讨论了其临床表现及处理方法。

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2
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引用本文的文献

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Early Use of Methylene Blue in Vasoplegic Syndrome: A 10-Year Propensity Score-Matched Cohort Study.亚甲蓝在血管麻痹综合征中的早期应用：一项为期10年的倾向评分匹配队列研究。
J Clin Med. 2022 Feb 20;11(4):1121. doi: 10.3390/jcm11041121.
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Serotonin syndrome in the perioperative period.围手术期血清素综合征
BJA Educ. 2020 Jan;20(1):10-17. doi: 10.1016/j.bjae.2019.10.003. Epub 2019 Dec 4.
3
Methylene blue may have a role in the treatment of COVID-19.亚甲蓝可能在治疗 COVID-19 中具有一定作用。
Med Hypotheses. 2020 Nov;144:110163. doi: 10.1016/j.mehy.2020.110163. Epub 2020 Aug 6.
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Metoclopramide-induced Serotonin Syndrome.甲氧氯普胺所致血清素综合征。
Cureus. 2019 Dec 12;11(12):e6359. doi: 10.7759/cureus.6359.
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Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques.与血清素综合征相关的重度动脉高血压的管理：基于系统评价技术的病例报告分析
Ther Adv Psychopharmacol. 2019 Mar 11;9:2045125318818814. doi: 10.1177/2045125318818814. eCollection 2019.
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From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue.从线粒体功能到神经保护——亚甲蓝的新作用。
Mol Neurobiol. 2018 Jun;55(6):5137-5153. doi: 10.1007/s12035-017-0712-2. Epub 2017 Aug 24.