Meegada Sreenath, Heda Rajiv Prakash, Satapathy Sanjaya, Verma Rajanshu
Internal Medicine, The University of Texas Health Science Center/Christus Good Shepherd Medical Center, Longview, USA.
Internal Medicine, University of Tennessee Health Science Center, Memphis, USA.
Cureus. 2019 Dec 12;11(12):e6359. doi: 10.7759/cureus.6359.
Serotonin syndrome is a clinical diagnosis characterized by a constellation of autonomic and neurological physical examination findings due to the use of one or more serotonergic agents. Due to high morbidity and mortality associated with this condition, high index of suspicion is required in making this diagnosis. Treatment is aimed at discontinuation of the offending agent and supportive care. We present a case of a 28-year-old woman who presented with acetaminophen toxicity, however developed iatrogenic serotonin syndrome due to use of scheduled intravenous metoclopramide. Metoclopramide, by itself, very rarely causes serotonin syndrome and typically results in this condition when used in combination with other pro-serotonergic agents.
血清素综合征是一种临床诊断，其特征是由于使用一种或多种血清素能药物而出现一系列自主神经和神经系统体格检查结果。由于这种疾病相关的高发病率和死亡率，做出该诊断需要高度的怀疑指数。治疗旨在停用致病药物并给予支持性护理。我们报告一例28岁女性病例，该患者最初表现为对乙酰氨基酚中毒，但因使用常规静脉注射甲氧氯普胺而发生医源性血清素综合征。甲氧氯普胺本身很少引起血清素综合征，通常与其他促血清素能药物联合使用时才会导致这种情况。
