Clark W B, Magnusson I, Walker C B, Marks R G
Periodontal Disease Research Center, College of Dentistry, University of Florida, Gainesville 32610.
J Clin Periodontol. 1989 Nov;16(10):630-5. doi: 10.1111/j.1600-051x.1989.tb01031.x.
A 6-month, double-blind controlled study was conducted on 101 subjects to determine the effect of Perimed antibacterial system, containing povidone-iodine (PVP-I) and hydrogen peroxide (H2O2), on established gingivitis. Subjects were randomly assigned to one of 4 treatment groups: PVP-I/H2O2, PVP-I/H2O, H2O2/H2O or H2O. Gingivitis was assessed by the papillary bleeding score (PBS) and plaque by a modified Quigley-Hein plaque index (PI) at baseline, 3, 12 and 24 weeks. The average baseline PBS and PI for the 4 groups ranged from 2.16-2.31 and 2.87-2.90, respectively. After baseline evaluation, subjects received a supra-gingival scaling and a subgingival irrigation with their respective rinse. Daily rinses were supervised and subgingival irrigation was repeated every 3 weeks. Duncan's multiple range test determined which groups differed from each other. The mean PI at 24 weeks was lower than at baseline in all groups. PVP-I had the lowest PI at all time points. The mean PBS at 24 weeks was 1.48 for PVP-I, 1.62 for H2O2, 1.88 for H2O and 1.34 for PVP-I/H2O2, a reduction from baseline of 31%, 27%, 18%, and 38% respectively. The difference between the PBS for PVP-I/H2O2 and H2O control was significant at each evaluation. There was a 70% reduction in sites with PBS greater than or equal to 3 for PVP-I/H2O2 between baseline and 24 weeks compared to a 34% decrease in the H2O group. It was concluded that the use of Perimed could be a beneficial adjunctive treatment for the prevention and control of gingivitis when used with routine oral hygiene procedures.
对101名受试者进行了一项为期6个月的双盲对照研究，以确定含有聚维酮碘（PVP-I）和过氧化氢（H2O2）的Perimed抗菌系统对已患牙龈炎的影响。受试者被随机分配到4个治疗组之一：PVP-I/H2O2、PVP-I/H2O、H2O2/H2O或H2O。在基线、第3、12和24周时，通过乳头出血评分（PBS）评估牙龈炎，通过改良的Quigley-Hein菌斑指数（PI）评估牙菌斑。4组的平均基线PBS和PI分别为2.16 - 2.31和2.87 - 2.90。基线评估后，受试者接受了龈上洁治和用各自的漱口水进行龈下冲洗。每日漱口受到监督，龈下冲洗每3周重复一次。Duncan多重极差检验确定哪些组之间存在差异。所有组在24周时的平均PI均低于基线。PVP-I在所有时间点的PI最低。PVP-I在24周时的平均PBS为1.48，H2O2为1.62，H2O为1.88，PVP-I/H2O2为1.34，与基线相比分别降低了31%、27%、18%和38%。在每次评估时，PVP-I/H2O2和H2O对照组的PBS差异均显著。与H2O组34%的下降相比，PVP-I/H2O2在基线和24周之间PBS大于或等于3的部位减少了70%。得出的结论是，当与常规口腔卫生程序一起使用时，Perimed的使用可能是预防和控制牙龈炎的一种有益辅助治疗方法。
