Maruniak J, Clark W B, Walker C B, Magnusson I, Marks R G, Taylor M, Clouser B
Periodontal Disease Research Center, University of Florida, Gainseville 32610.
J Clin Periodontol. 1992 Jan;19(1):19-23. doi: 10.1111/j.1600-051x.1992.tb01143.x.
The aim of this study was to evaluate the effect of 3 mouthrinses, Listerine Antiseptic (thymol), Peridex (chlorhexidine), Perimed (povidone iodine and hydrogen peroxide), and a placebo (water) on the development of dental plaque and gingivitis, when used as the only oral hygiene procedure for 14 days. 71 subjects were entered into a randomized, double-blind study. At the baseline examination, papillary bleeding score (PBS), and plaque index (PI) were registered, after which subjects received supragingival prophylaxis and were assigned to 1 of 4 study cells. Subjects were asked to refrain from all oral hygiene procedures except for the supervised 14-day 2 x daily rinsing with the assigned preparation. At day 14, the same clinical parameters were again registered. Statistical analysis was performed by a one-way analysis of variance (ANOVA) to compare the 4 groups, followed by Duncan's multiple range test to determine specific group differences. At baseline, average PBS and PI scores were similar for all 4 groups. After 14 days, the average PBS for Peridex and Perimed was significantly lower than for Listerine Antiseptic and water. The frequency of interdental units with a PBS greater than 2 was significantly lower for Peridex and Perimed than for Listerine Antiseptic and water. We concluded that both Peridex and Perimed were effective in reducing plaque and gingivitis when used as a 2 x daily mouthrinse by subjects refraining from other oral hygiene procedures. In vitro, a synergistic effect was assumed when inhibition was achieved with Perimed at the same or greater dilution than was achieved with povidone-iodine alone.
本研究旨在评估三种漱口水，即利斯特林抗菌漱口水（百里酚）、派丽奥（氯己定）、佩里美（聚维酮碘和过氧化氢）以及一种安慰剂（水），在作为唯一口腔卫生措施使用14天时，对牙菌斑形成和牙龈炎的影响。71名受试者进入一项随机双盲研究。在基线检查时，记录牙龈乳头出血评分（PBS）和菌斑指数（PI），之后受试者接受龈上洁治，并被分配到4个研究组中的一组。受试者被要求除了在监督下每天用指定制剂漱口两次共14天之外，避免所有口腔卫生措施。在第14天，再次记录相同的临床参数。通过单因素方差分析（ANOVA）对4组进行统计分析，随后进行邓肯多重极差检验以确定具体组间差异。在基线时，所有4组的平均PBS和PI评分相似。14天后，派丽奥和佩里美的平均PBS显著低于利斯特林抗菌漱口水和水。PBS大于2的牙间隙单位频率，派丽奥和佩里美显著低于利斯特林抗菌漱口水和水。我们得出结论，当受试者避免其他口腔卫生措施，每天使用派丽奥和佩里美漱口两次时，二者在减少牙菌斑和牙龈炎方面均有效。在体外实验中，当佩里美在与单独使用聚维酮碘相同或更高稀释度时实现抑制效果，推测存在协同作用。
