Muniz Francisco Wilker Mustafa Gomes, Cavagni Juliano, Langa Gerson Pedro José, Stewart Bernal, Malheiros Zilson, Rösing Cassiano Kuchenbecker
Department of Periodontology, Federal University of Pelotas, Pelotas, Brazil.
Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Int J Dent. 2020 Oct 31;2020:8841722. doi: 10.1155/2020/8841722. eCollection 2020.
Hydrogen peroxide (HO) has been used for more than a century clinically to control plaque and gingival inflammation, with unclear supporting evidence.
The aim of the present systematic review of the literature is to assess the effect of mouth rinses with HO on dental plaque, gingival inflammation, and oral microorganisms.
Five databases (PubMed, Scopus, Embase, Cochrane Library, and Web of Science) were searched with the following focused question: what is the effect of hydrogen peroxide, in comparison to chlorhexidine or to a placebo solution, in oral microbiota control, dental plaque, and gingival inflammatory outcomes? Two independent examiners retrieved the articles and evaluated the evidence.
The majority of included studies were performed with 1.5% HO. Results related to plaque accumulation generally demonstrate a slightly better effect of HO as compared to placebo mouth rinses, however with a lower performance as compared to chlorhexidine. In terms of gingival inflammation, HO performs better than placebo and more clearly demonstrates an anti-inflammation effect. No studies evaluated the effect of HO against viruses or fungi. In terms of bacteria, HO demonstrates an antibacterial effect.
Rinsing with HO has the potential to affect plaque, gingivitis, and oral bacteria, as compared to placebo. However, the antibacterial results are not comparable to the performance of chlorhexidine.
过氧化氢（HO）在临床上用于控制牙菌斑和牙龈炎症已有一个多世纪，但支持证据尚不明确。
本系统文献综述旨在评估含HO漱口水对牙菌斑、牙龈炎症和口腔微生物的影响。
使用以下重点问题检索五个数据库（PubMed、Scopus、Embase、Cochrane图书馆和科学网）：与氯己定或安慰剂溶液相比，过氧化氢在控制口腔微生物群、牙菌斑和牙龈炎症结果方面有何效果？两名独立审查员检索文章并评估证据。
大多数纳入研究使用的是1.5%的HO。与牙菌斑积聚相关的结果通常表明，与安慰剂漱口水相比，HO的效果略好，但与氯己定相比效果较差。在牙龈炎症方面，HO比安慰剂表现更好，更明显地显示出抗炎作用。没有研究评估HO对病毒或真菌的影响。在细菌方面，HO显示出抗菌作用。
与安慰剂相比，用HO漱口有可能影响牙菌斑、牙龈炎和口腔细菌。然而，抗菌结果与氯己定的性能不可比。
