Das Lipsa, Samprathi Madhusudan, Shukla Umesh, Bandyopadhyay Debapriya, Das Rashmi Ranjan
Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Orissa, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, Orissa, India.
Indian J Pediatr. 2016 Jul;83(7):720-2. doi: 10.1007/s12098-016-2062-x. Epub 2016 Mar 3.
Hypertriglyceridemia has been rarely described with thalassemia, an entity called hypertriglyceridemia-thalassemia syndrome. The authors describe a young infant diagnosed with thalassemia major with severe hypertriglyceridemia. The presence of severe hypertriglyceridemia in this child which rapidly resolved after transfusion, probably suggests a self limited mechanism which may not require therapy. Though hypertriglyceridemia has been reported with hemolytic anemias, the mechanism is unclear. This case illustrates that thalassemia may be associated with hypertriglyceridemia; once familial and secondary causes are ruled out, clinicians may wait for spontaneous resolution before considering specific therapy.
高甘油三酯血症与地中海贫血（一种称为高甘油三酯血症 - 地中海贫血综合征的病症）的关联鲜有描述。作者报告了一名诊断为重型地中海贫血并伴有严重高甘油三酯血症的幼儿。该患儿出现的严重高甘油三酯血症在输血后迅速缓解，这可能提示一种自限性机制，或许无需治疗。虽然溶血性贫血患者中曾有高甘油三酯血症的报道，但其机制尚不清楚。该病例表明地中海贫血可能与高甘油三酯血症有关；一旦排除家族性和继发性病因，临床医生在考虑特定治疗之前可等待其自发缓解。
