Widén Cecilia, Holmer Helene, Coleman Michael, Tudor Marian, Ohlsson Ola, Sättlin Susanna, Renvert Stefan, Persson Goesta Rutger
School of Health and Society, Kristianstad University, Kristianstad, Sweden.
Kristianstad Central Hospital, Kristianstad, Sweden.
J Clin Periodontol. 2016 Sep;43(9):713-9. doi: 10.1111/jcpe.12540. Epub 2016 Jul 2.
A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity.
In a case-control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology.
A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p < 0.001). Independent of periodontal conditions, individuals with ACS had significantly higher serum levels of IL8 (mean: 44.3 and 40.0 pg/ml) and vascular endothelial growth factor (VEGF) (mean: 82.3 and 55.3 pg/ml) than control individuals. A diagnosis of periodontitis made no difference in serum cytokine expressions.
Elevated serum levels of VEGF were associated with ACS. Serum cytokine expression in individuals with ACS is unrelated to periodontal conditions.
急性冠状动脉综合征（ACS）与牙周炎之间的因果关系尚未明确。本研究旨在评估合并或未合并ACS或牙周疾病的个体之间血清细胞因子水平的差异。
在一项病例对照研究中，纳入了患有ACS的个体（78例，女性占10.3%）和匹配的健康对照者（78例，女性占28.2%）。进行医学和牙科检查以诊断ACS和牙周炎。使用Luminex技术评估血清细胞因子水平。
ACS组和对照组中分别有52.6%和12.8%的个体被诊断为牙周炎。患有ACS的个体同时患有牙周炎的未调整比值比为7.5（95%置信区间：3.4，16.8，p<0.001）。与牙周状况无关，患有ACS的个体血清白细胞介素8（IL8）水平（平均值：44.3和40.0 pg/ml）和血管内皮生长因子（VEGF）水平（平均值：82.3和55.3 pg/ml）显著高于对照个体。牙周炎的诊断对血清细胞因子表达没有影响。
血清VEGF水平升高与ACS相关。患有ACS的个体的血清细胞因子表达与牙周状况无关。
