Tang Kuangyun, Wu Yongjia, Zheng Qianhan, Chen Xuepeng
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Front Cardiovasc Med. 2023 Sep 4;10:1255722. doi: 10.3389/fcvm.2023.1255722. eCollection 2023.
Periodontitis (PD) and cardiovascular diseases (CVD) rank among the most prevalent pathologies worldwide, and their correlation has been a subject of prolonged investigation. Numerous studies suggest shared etiological factors; however, a definitive causal connection remains unestablished. The objective of this study was to employ bibliometric and visual analyses in order to comprehensively examine the overarching characteristics, focal areas of research, and prospective trends pertaining to the PD-CVD relationship.
We sourced articles, reviews, and online publications on PD- and CVD- research from the Web of Science Core Collection (WoSCC) spanning from January 1, 1993, to May 15, 2023. A triad of analytical tools (R-Bibliometrix, VOSviewer 1.6.19, and CiteSpace 6.2.R3) were utilized to facilitate collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection.
Out of the 1,116 publications that fulfilled the eligibility criteria in the WoSCC database, the comprehensive characteristics analysis divulged a sustained growth trend in publication frequency. In the cluster analysis of reference co-citation and keyword co-occurrence, prominent themes such as "periodontitis", "cardiovascular diseases", "inflammation", "", and "atherosclerosis" consistently emerged. Contemporary topics such as "peri-implantitis," "COVID-19", "cardiovascular risk factors," and "endocarditis" were pinpointed as burgeoning research hotspots.
Based on this bibliometric study, in the field of association studies between PD and CVD, the etiologic mechanisms of both diseases have been intensively studied in the last three decades. Periodontal pathogens might serve as potential initiating factors linking PD and CVD. Inflammation may constitute a significant etiological factor shared by both diseases. Several emerging topics, such as COVID-19 and peri-implantitis, exhibit promising potential. This exhaustive overview casts light on pivotal research arenas, augmenting the field's understanding and stimulating further scholarly investigations.
牙周炎（PD）和心血管疾病（CVD）是全球最常见的疾病，它们之间的相关性一直是长期研究的主题。许多研究表明存在共同的病因；然而，明确的因果关系尚未确立。本研究的目的是采用文献计量学和可视化分析，以全面考察PD-CVD关系的总体特征、研究重点领域和未来趋势。
我们从科学网核心合集（WoSCC）中获取了1993年1月1日至2023年5月15日期间关于PD和CVD研究的文章、综述及在线出版物。使用了三种分析工具（R-Bibliometrix、VOSviewer 1.6.19和CiteSpace 6.2.R3）来进行合作网络分析、共被引分析、共现分析和引文突发检测。
在WoSCC数据库中符合纳入标准的1116篇出版物中，综合特征分析显示出版频率呈持续增长趋势。在参考文献共被引和关键词共现的聚类分析中，“牙周炎”“心血管疾病”“炎症”“”和“动脉粥样硬化”等突出主题始终出现。“种植体周围炎”“COVID-19”“心血管危险因素”和“心内膜炎”等当代主题被确定为新兴的研究热点。
基于这项文献计量学研究，在PD和CVD关联研究领域，过去三十年对这两种疾病的病因机制都进行了深入研究。牙周病原体可能是连接PD和CVD的潜在起始因素。炎症可能是这两种疾病共有的重要病因因素。一些新兴主题，如COVID-19和种植体周围炎，显示出有前景的潜力。这一详尽的概述揭示了关键的研究领域，增进了该领域理解并激发了进一步的学术研究。
