Badr Dana, Abadi Rami, Kurban Mazen, Abbas Ossama
Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.
Pediatr Dermatol. 2016 May;33(3):301-6. doi: 10.1111/pde.12824. Epub 2016 Mar 2.
BACKGROUND/OBJECTIVES: In addition to several infectious and neoplastic cutaneous entities, plasmacytoid dendritic cells (pDCs) have been shown to be involved in the pathogenesis of multiple cutaneous inflammatory and autoimmune disorders, including those characterized histologically by an "interface dermatitis" pattern such as lupus or lichen planus (LP), but their role in lichen striatus (LS), which is also known to have this histologic inflammatory pattern, has never been studied. The objective of the study was to investigate the role of pDCs in LS.
Fifteen LS patients were found in our database and were immunohistochemically tested for pDC occurrence and activity using anti-blood-derived dendritic cell antigen-2 and anti-myxovirus resistance protein A (MxA) antibodies, respectively. These individuals were also compared with 15 individuals with LP.
pDCs were present in all individuals with LS and LP, but they were less abundant in those with LS, although MxA (surrogate marker of local type I interferon production and thus an indirect assessment of pDC activity) was similarly intense and diffuse in all individuals with LS and LP. In addition to being part of the upper dermal inflammatory bandlike infiltrate as in LP, LS cases, unlike LP, also showed perieccrine pDCs.
pDCs constitute a central component of the inflammatory infiltrate in LS, suggesting a significant role in its pathogenesis. pDC distribution (perieccrine distribution) could also help in microscopically differentiating LS from LP.
背景/目的：除了几种感染性和肿瘤性皮肤疾病外，浆细胞样树突状细胞（pDC）已被证明参与多种皮肤炎症和自身免疫性疾病的发病机制，包括那些组织学上以“界面性皮炎”模式为特征的疾病，如狼疮或扁平苔藓（LP），但它们在同样具有这种组织学炎症模式的线状苔藓（LS）中的作用从未被研究过。本研究的目的是探讨pDC在LS中的作用。
在我们的数据库中发现了15例LS患者，并分别使用抗血源性树突状细胞抗原-2和抗黏液病毒抗性蛋白A（MxA）抗体对pDC的存在和活性进行免疫组织化学检测。这些个体还与15例LP患者进行了比较。
所有LS和LP患者体内均存在pDC，但LS患者体内的pDC数量较少，尽管MxA（局部I型干扰素产生的替代标志物，因此是对pDC活性的间接评估）在所有LS和LP患者体内的强度和分布相似。与LP一样，LS病例中pDC也是真皮上部炎症带状浸润的一部分，但与LP不同的是，LS病例还显示有汗腺周围pDC。
pDC是LS炎症浸润的核心组成部分，提示其在发病机制中起重要作用。pDC的分布（汗腺周围分布）也有助于在显微镜下区分LS和LP。
