Huang Wen-Chuan, Chen Chung-Yu, Lin Shun-Jin, Chang Chao-Sung
a School of Pharmacy, Master Program in Clinical Pharmacy , Kaohsiung Medical University , Kaohsiung , Taiwan.
b Department of Pharmacy , Kaohsiung Medical University Hospital , Kaohsiung , Taiwan.
Expert Rev Anticancer Ther. 2016;16(4):423-32. doi: 10.1586/14737140.2016.1159515. Epub 2016 Mar 16.
Many studies have demonstrated that non-adherence to oral anticancer drugs (OACDs) has challenged treatment efficacy. Otherwise, few validated tools exist to measure patients' adherence to medication regimen in clinical practice. To synthesize previous studies on adherence by cancer patients taking OACDs, especially in targeted therapy, a systematic search of several electronic databases was conducted. We analyzed existing scales' contents for various cancer patients and outcomes of studies assessing adherence. However, a well-validated scale designed particularly for OACD adherence is still lacking. Most adherence scales used in the studies reviewed contain items focused on measuring patients' medication-taking behavior more than their barriers to medication compliance and beliefs. However, non-adherence to OACDs is a complex phenomenon, and drug-taking barriers and patient beliefs significantly affect patients' non-adherence. To understand the key drivers and predisposing factors for non-adherence, we need to develop a well-validated, multidimensional scale.
许多研究表明，口服抗癌药物（OACD）的不依从性对治疗效果构成了挑战。此外，在临床实践中，几乎没有经过验证的工具来衡量患者对药物治疗方案的依从性。为了综合以往关于服用OACD的癌症患者依从性的研究，特别是在靶向治疗方面，我们对几个电子数据库进行了系统检索。我们分析了现有量表针对各类癌症患者的内容以及评估依从性的研究结果。然而，仍然缺乏一个专门为OACD依从性设计的经过充分验证的量表。在所审查的研究中使用的大多数依从性量表包含的项目更多地侧重于测量患者的服药行为，而不是他们在药物依从性方面的障碍和信念。然而，OACD的不依从是一个复杂的现象，服药障碍和患者信念会显著影响患者的不依从性。为了了解不依从的关键驱动因素和诱发因素，我们需要开发一个经过充分验证的多维量表。
