胞质抗体受体TRIM21介导的协同中和与免疫激活
Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21.
作者信息
Fletcher Adam J, James Leo C
机构信息
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
出版信息
J Virol. 2016 Apr 29;90(10):4856-4859. doi: 10.1128/JVI.00050-16. Print 2016 May 15.
Abstract
TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity. We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector. We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.
摘要
TRIM21是一种高亲和力抗体受体，在哺乳动物细胞的胞质溶胶中独特表达。在此，我们总结了它在将抗体保护扩展到细胞内环境以及使非专职细胞受益于适应性免疫方面的作用。我们重点介绍了最近揭示TRIM21如何作为免疫传感器和效应器发挥作用的研究工作。我们还回顾了TRIM21如何与其他先天免疫受体协同作用以促进整合的抗病毒反应。
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