胃癌胃切除术后发生肺结核的危险因素。
Risk factors for tuberculosis after gastrectomy in gastric cancer.
作者信息
Jung Won Jai, Park Young Mok, Song Joo Han, Chung Kyung Soo, Kim Song Yee, Kim Eun Young, Jung Ji Ye, Park Moo Suk, Kim Young Sam, Kim Se Kyu, Chang Joon, Noh Sung Hoon, An Ji Yeong, Kang Young Ae
机构信息
Won Jai Jung, Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul 120-752, South Korea.
出版信息
World J Gastroenterol. 2016 Feb 28;22(8):2585-91. doi: 10.3748/wjg.v22.i8.2585.
AIM
To examine incidence of tuberculosis (TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer.
METHODS
A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios (SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed.
RESULTS
Among the 1776 gastrectomy patients, 0.9% (16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher than that in the general population (SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio (OR) = 7.1, P < 0.001], lower body mass index (BMI) (kg/m(2); OR = 1.21, P = 0.043) and gastrectomy extent (total gastrectomy vs subtotal gastrectomy) (OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis.
CONCLUSION
TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer.
目的
研究胃癌患者胃切除术后结核病（TB）的发病率，并探讨胃癌患者胃切除术后发生TB的危险因素。
方法
2007年1月至2009年12月，在韩国首尔一家大学附属医院对胃癌胃切除患者进行了一项回顾性队列研究。我们查阅了患者的病历，并收集了与TB风险、手术和胃癌相关的数据。计算TB的标准化发病率（SIRs），以比较胃切除患者与韩国普通人群中TB的发病率，并分析胃切除术后TB的危险因素。
结果
在1776例胃切除患者中，0.9%（16/1776）发生了胃切除术后TB，每年每100000例患者的发病率为223.7例。经性别和年龄调整后，胃切除患者中TB的总体发病率显著高于普通人群（SIR = 2.22，95%CI：1.27 - 3.60）。多因素分析显示，既往TB感染[比值比（OR）= 7.1，P < 0.001]、较低的体重指数（BMI）（kg/m²；OR = 1.21，P = 0.043）和胃切除范围（全胃切除与次全胃切除）（OR = 3.48，P = 0.017）是胃切除术后发生TB的重要危险因素。
结论
胃切除术后TB发病率高于普通人群。既往TB感染、较低的BMI和全胃切除是胃癌患者胃切除术后发生TB的危险因素。
Zotero 插件