癌症基因组学
Cancer Genomics.
作者信息
Mardis Elaine
机构信息
McDonnell Genome Institute, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St. Louis, MO, 63108, USA.
出版信息
F1000Res. 2015 Oct 28;4. doi: 10.12688/f1000research.6645.1. eCollection 2015.
Abstract
Modern cancer genomics has emerged from the combination of the Human Genome Reference, massively parallel sequencing, and the comparison of tumor to normal DNA sequences, revealing novel insights into the cancer genome and its amazing diversity. Recent developments in applying our knowledge of cancer genomics have focused on the utility of these data for clinical applications. The emergent results of this translation into the clinical setting already are changing the clinical care and monitoring of cancer patients.
摘要
现代癌症基因组学源于人类基因组参考序列、大规模平行测序以及肿瘤与正常DNA序列比较的结合，揭示了对癌症基因组及其惊人多样性的全新见解。应用癌症基因组学知识的最新进展集中在这些数据在临床应用中的效用上。这种转化到临床环境中的初步结果已经在改变癌症患者的临床护理和监测。
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