库普弗细胞的代谢与功能。
Kupffer Cell Metabolism and Function.
作者信息
Nguyen-Lefebvre Anh Thu, Horuzsko Anatolij
机构信息
Cancer Center, Molecular Oncology Program, Georgia Regents University, Augusta, GA, 30912, USA.
Cancer Center, Molecular Oncology Program, Georgia Regents University, Augusta, GA, 30912, USA; Cancer Center, Molecular Oncology Program, Department of Medicine, Georgia Regents University, 1410 Laney Walker Blvd., Augusta, GA, 30912, USA.
出版信息
J Enzymol Metab. 2015;1(1). Epub 2015 Aug 14.
Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections. Under pathological conditions, they are activated by different components and can differentiate into M1-like (classical) or M2-like (alternative) macrophages. The metabolism of classical or alternative activated Kupffer cells will determine their functions in liver damage. Special functions and metabolism of Kupffer cells suggest that they are an attractive target for therapy of liver inflammation and related diseases, including cancer and infectious diseases. Here we review the different types of Kupffer cells and their metabolism and functions in physiological and pathological conditions.
库普弗细胞是肝脏中的常驻巨噬细胞，在维持肝脏功能方面发挥着关键作用。在生理条件下，它们是首批固有免疫细胞，可保护肝脏免受细菌感染。在病理条件下，它们会被不同成分激活，并可分化为M1样（经典型）或M2样（替代型）巨噬细胞。经典激活或替代激活的库普弗细胞的代谢将决定它们在肝损伤中的功能。库普弗细胞的特殊功能和代谢表明，它们是治疗肝脏炎症及相关疾病（包括癌症和传染病）的一个有吸引力的靶点。在此，我们综述了不同类型的库普弗细胞及其在生理和病理条件下的代谢与功能。
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