靶向NMDAR GluN2A亚基的新型PAMs
Novel PAMs Targeting NMDAR GluN2A Subunit.
作者信息
Xiang Zixiu, Conn P Jeffrey
机构信息
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
出版信息
Neuron. 2016 Mar 2;89(5):884-6. doi: 10.1016/j.neuron.2016.02.025.
Abstract
In this issue of Neuron, Hackos et al. (2016) report the discovery of novel positive allosteric modulators that are highly selective for GluN2A-containing NMDA receptors. This novel class of PAMs shows distinct effects on synaptic plasticity.
摘要
在本期《神经元》杂志中，哈科斯等人（2016年）报告了新型正变构调节剂的发现，这些调节剂对含GluN2A的N-甲基-D-天冬氨酸受体具有高度选择性。这类新型的变构增效剂对突触可塑性表现出不同的影响。
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