Department of Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Muengersdorf 6, 50933 Cologne, Germany.
Int J Mol Sci. 2016 Mar 1;17(3):326. doi: 10.3390/ijms17030326.
Based on their ability to recognize and eliminate various endo- and exogenous pathogens as well as pathological alterations, Natural Killer (NK) cells represent an important part of the cellular innate immune system. Although the knowledge about their function is growing, little is known about their development and regulation on the molecular level. Research of the past decade suggests that modifications of the chromatin, which do not affect the base sequence of the DNA, also known as epigenetic alterations, are strongly involved in these processes. Here, the impact of epigenetic modifications on the development as well as the expression of important activating and inhibiting NK-cell receptors and their effector function is reviewed. Furthermore, external stimuli such as physical activity and their influence on the epigenetic level are discussed.
基于其识别和消除各种内源性和外源性病原体以及病理改变的能力，自然杀伤 (NK) 细胞是细胞固有免疫系统的重要组成部分。尽管人们对其功能的了解不断增加，但对其在分子水平上的发育和调节知之甚少。过去十年的研究表明，不影响 DNA 碱基序列的染色质修饰，也称为表观遗传改变，强烈参与这些过程。本文综述了表观遗传修饰对重要激活和抑制 NK 细胞受体的发育和表达及其效应功能的影响。此外，还讨论了诸如体育活动等外部刺激及其对表观遗传水平的影响。
