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髓系C型凝集素受体（Mincle）介导的抗炎性白细胞介素-10（IL-10）反应在体外对白细胞介素-12（IL-12）起反调节作用。

Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.

作者信息

Patin Emmanuel C, Willcocks Sam, Orr Selinda, Ward Theresa H, Lang Roland, Schaible Ulrich E

机构信息

Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK Priority Area Infections, Research Center Borstel, Borstel, Germany Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

Department of Immunology and Infection, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

Innate Immun. 2016 Apr;22(3):181-5. doi: 10.1177/1753425916636671. Epub 2016 Mar 2.

DOI:10.1177/1753425916636671
PMID:26939595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4826952/
Abstract

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

摘要

巨噬细胞诱导性C型凝集素（Mincle）在抗炎反应中的作用尚未完全明确。在此，我们表明海藻糖二霉菌酸酯或分枝杆菌与Mincle结合可促进巨噬细胞中白细胞介素10（IL-10）的产生，进而导致白细胞介素12p40分泌下调。因此，Mincle介导促炎和抗炎反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda9/4826952/44531eecf504/10.1177_1753425916636671-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda9/4826952/187bf07a7901/10.1177_1753425916636671-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda9/4826952/44531eecf504/10.1177_1753425916636671-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda9/4826952/187bf07a7901/10.1177_1753425916636671-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fda9/4826952/44531eecf504/10.1177_1753425916636671-fig2.jpg

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Front Immunol. 2014 Jun 23;5:288. doi: 10.3389/fimmu.2014.00288. eCollection 2014.
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iScience. 2024 Aug 8;27(9):110700. doi: 10.1016/j.isci.2024.110700. eCollection 2024 Sep 20.
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5
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Adv Exp Med Biol. 2013;783:121-40. doi: 10.1007/978-1-4614-6111-1_7.
6
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