模式识别受体与炎症。

Pattern recognition receptors and inflammation.

机构信息

WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.

出版信息

Cell. 2010 Mar 19;140(6):805-20. doi: 10.1016/j.cell.2010.01.022.

DOI:10.1016/j.cell.2010.01.022

PMID:20303872

Abstract

Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses.

摘要

微生物感染细胞会激活炎症反应。感染的初始感知是由先天模式识别受体（PRRs）介导的，这些受体包括 Toll 样受体、RIG-I 样受体、NOD 样受体和 C 型凝集素受体。这些 PRRs 触发的细胞内信号级联反应导致炎症介质的转录表达，协调病原体和感染细胞的清除。然而，该系统的异常激活会导致免疫缺陷、败血症休克或自身免疫的诱导。在这篇综述中，我们讨论了 PRRs 的作用、它们的信号通路以及它们如何控制炎症反应。