Liu Shenghua, Zou Lujia, Mao Shanhua, Zhang Limin, Xu Hua, Yang Tian, Jiang Haowen, Ding Qiang
Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China; Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China; Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Cryobiology. 2016 Apr;72(2):157-60. doi: 10.1016/j.cryobiol.2016.02.007. Epub 2016 Mar 3.
The poor quality of initial transurethral resection (TUR) would leave residual tumor and compromise the prognosis. The common therapeutic option is to perform re-TUR, which adds burden to patients. We assumed that cryoablation could be applied as adjuvant therapy combined with TUR, thus lead to maxium tumor control. In our study, we investigated the safety and effects of focal bladder wall cryoablation in beagle model using a novel cryoablation balloon probe. Temperature was recorded throughout the freeze process in different parts of the bladder. The bladder was harvested immediately, 2 weeks or 3 months after surgery for histological evaluation. The results demonstrated cryoablation using our newly designed probe is safe and effective. Two-minute cryoablation could induce necrosis within 2-cm range in diameter to superficial muscle layer. The findings provided us reference before cryoablation could be applied in clinical practice.
初次经尿道切除术（TUR）质量不佳会残留肿瘤并影响预后。常见的治疗选择是再次进行经尿道切除术（re-TUR），这给患者增加了负担。我们设想冷冻消融可作为辅助治疗与经尿道切除术联合应用，从而实现最大程度的肿瘤控制。在我们的研究中，我们使用新型冷冻消融球囊探头在比格犬模型中研究了局灶性膀胱壁冷冻消融的安全性和效果。在膀胱不同部位的冷冻过程中记录温度。术后立即、2周或3个月时收获膀胱进行组织学评估。结果表明，使用我们新设计的探头进行冷冻消融是安全有效的。两分钟的冷冻消融可在直径2厘米范围内诱导至浅表肌层的坏死。这些发现为冷冻消融应用于临床实践提供了参考。
