Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China; Shanghai Municipal Key Clinical Specialty of Gynecologic Oncology, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Shanghai Municipal Key Clinical Specialty of Gynecologic Oncology, Shanghai, 200030, China; Shanghai Key Laboratory of Embryo Original Diseases Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Cryobiology. 2020 Jun;94:89-94. doi: 10.1016/j.cryobiol.2020.04.004. Epub 2020 Apr 17.
Young patients with early endometrial cancer have a strong desire to retain reproductive function, which require us to develop a therapeutic method that can not only assure the complete resection of tumor but also retain the uterine integrity. In the present study, we proposed a fertility-sparing surgery option that combined hysteroscopic resection with cryoablation to achieve this goal. To verify the safety and effectiveness of cryoablation for local uterine wall, we designed the experiment in pig model using a novel cryoablation balloon probe. In the process of freezing and thawing, the temperature of different parts of the uterus was measured in real time. The uterus was harvested immediately, three weeks after cryotherapy for histological evaluation. The results demonstrated cryoablation using the new cryoprobe is safe and effective. The effective freezing range can cover a range of 2 cm in diameter at least. This study provided us evidence before cryoablation could be applied in clinical practice of fertility-sparing treatment for young women with early endometrial cancer.
年轻的早期子宫内膜癌患者强烈希望保留生育功能，这要求我们开发一种既能保证肿瘤完全切除又能保留子宫完整性的治疗方法。在本研究中，我们提出了一种将宫腔镜切除术与冷冻消融相结合的保留生育力手术选择，以实现这一目标。为了验证冷冻消融治疗子宫局部壁的安全性和有效性，我们使用新型冷冻消融球囊探头在猪模型中设计了实验。在冷冻和解冻过程中，实时测量子宫不同部位的温度。冷冻治疗后 3 周立即采集子宫，进行组织学评估。结果表明，新型冷冻探针的冷冻消融是安全有效的。有效冷冻范围至少可以覆盖 2cm 直径的范围。这项研究为冷冻消融在年轻早期子宫内膜癌患者保留生育力治疗的临床应用提供了证据。
