Thompson Laura H, Nugent Zoann, Blanchard James F, Ens Carla, Yu Bo Nancy
Epidemiology and Surveillance Unit, Public Health and Primary Health Care Division, Manitoba Health, Healthy Living & Seniors, Winnipeg, R3B 3 M9, Manitoba, Canada.
Centre for Global Public Health, University of Manitoba, Winnipeg, Canada.
BMC Public Health. 2016 Mar 3;16:219. doi: 10.1186/s12889-016-2885-4.
Anogenital warts (AGW) are caused by the most common sexually transmitted infection, human papillomavirus. The objective of this study was to examine AGW incidence from 1990 to 2011 by sex, age, income quintile, and residential area category (urban/rural). The study period included the initiation of school-based HPV vaccination for girls in the sixth grade, which began in 2008. The data presented in this paper may also be useful for establishing baseline rates of AGW incidence which may be used to evaluate the success of the school-based HPV immunization program.
Cases of anogenital warts were identified using Manitoba's administrative databases of Physician Claims and Hospital Discharge Abstracts. Annual age-standardized incidence in Manitoba from 1990 to 2011 was calculated. Incident AGW rates were compared by sex, age group, residential area category (urban/rural), and household income quintile using logistic regression. Joinpoint regression analyses were used to evaluate the time trends of AGW.
Prior to 2000, AGW incidence was higher among females than males. However, from 2000 to 2011 the incidence was higher among males and increased steadily over time. AGW incidence tended to peak in younger age groups among females compared to males. Females and males living in urban areas had nearly twice the odds of AGW occurrence compared to those in rural areas.
There is a need for education about AGW in male population. The upcoming initiation of HPV vaccination among boys may reduce the incidence and should be evaluated.
肛门生殖器疣（AGW）由最常见的性传播感染——人乳头瘤病毒引起。本研究的目的是按性别、年龄、收入五分位数和居住地区类别（城市/农村），研究1990年至2011年期间肛门生殖器疣的发病率。研究期间包括2008年开始的针对六年级女生的校内人乳头瘤病毒疫苗接种。本文所呈现的数据对于确定肛门生殖器疣发病率的基线率可能也有用，该基线率可用于评估校内人乳头瘤病毒免疫计划的成效。
利用曼尼托巴省的医生索赔和医院出院摘要行政数据库来确定肛门生殖器疣病例。计算了1990年至2011年曼尼托巴省的年度年龄标准化发病率。使用逻辑回归按性别、年龄组、居住地区类别（城市/农村）和家庭收入五分位数比较肛门生殖器疣的发病率。采用Joinpoint回归分析来评估肛门生殖器疣的时间趋势。
2000年之前，女性肛门生殖器疣的发病率高于男性。然而，从2000年到2011年，男性的发病率更高且随时间稳步上升。与男性相比，女性肛门生殖器疣的发病率在较年轻年龄组中往往达到峰值。与农村地区的人相比，居住在城市地区的女性和男性发生肛门生殖器疣的几率几乎高出一倍。
需要对男性人群开展关于肛门生殖器疣的教育。即将在男孩中开始的人乳头瘤病毒疫苗接种可能会降低发病率，应对此进行评估。
