Milcovich Gesmi, Antunes Filipe, Golob Samuel, Farra Rossella, Grassi Mario, Voinovich Dario, Grassi Gabriele, Asaro Fioretta
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127, Italy.
Chemistry Department, University of Coimbra, Coimbra, 3004-535, Portugal.
J Biomed Mater Res A. 2016 Jul;104(7):1668-79. doi: 10.1002/jbm.a.35698. Epub 2016 Mar 16.
In this study, negatively charged catanionic vesicles/hydrophobically modified hydroxyethylcellulose polymers thermo-responsive hydrogels have been fabricated. Vesicular aggregates were found to act as multifunctional junctions for networking of modified-cellulose water solutions. The contributions of the electrostatic and hydrophobic interactions were evaluated by changing either vesicles composition or the polymer hydrophobic substitution. Thermal-induced size and lamellarity of hydrogel-enclosed vesicles were detected, with further polygonal shape changes induced by cellulose-based polymer addition. The thermal transition was also found to tune hydrogel mechanical behaviour. The network formation was further assessed through molecular insights, which allow to determine the arrangement of the polymer chains on the vesicles' surface. The examined systems exhibited interesting thermo-responsive characteristics. Thus, vesicularly cross-linked hydrogels herein presented can offer a wide variety of applications, i.e. in biomedical field, as multi-drug delivery systems, thanks to their ability to provide for different environments to guest molecules, comprising bulk water, vesicles' interior and bilayers, sites on polymeric chains. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1668-1679, 2016.
在本研究中，制备了带负电荷的阴阳离子囊泡/疏水改性羟乙基纤维素聚合物热响应水凝胶。发现囊泡聚集体作为改性纤维素水溶液网络的多功能连接点。通过改变囊泡组成或聚合物疏水取代来评估静电和疏水相互作用的贡献。检测了水凝胶包裹囊泡的热诱导尺寸和片层结构变化，添加基于纤维素的聚合物会进一步引起多边形形状变化。还发现热转变可调节水凝胶的力学行为。通过分子层面的深入研究进一步评估了网络形成情况，这有助于确定聚合物链在囊泡表面的排列方式。所研究的体系表现出有趣的热响应特性。因此，本文介绍的囊泡交联水凝胶由于能够为客体分子提供包括本体水、囊泡内部和双层膜、聚合物链上的位点等不同环境，在生物医学领域作为多药物递送系统可提供广泛的应用。© 2016 威利期刊公司。《生物医学材料研究杂志》A 部分：104A: 1668 - 1679, 2016。
